Tenofovir, currently marketed as the prodrug tenofovir disoproxil fumarate, is used clinically to treat patients with HIV/AIDS. The oral bioavailability of tenofovir is relatively low, limiting its clinical effectiveness. Encapsulation of tenofovir within modified long-circulating liposomes would deliver this hydrophilic anti-HIV drug to the reticuloendothelial system for better therapeutic eff...

OBJECTIVES The aim of our study was to assess the impact of plasma HIV-1 RNA level [viral load (VL)] variation and tenofovir exposure on kidney functions by analysing changes in calculated glomerular filtration rates (GFRs) over a 48 week period in patients with mild renal impairment. PATIENTS AND METHODS A prospective observational study that included data from all consecutive HIV-infected p...

Tenofovir gel is being evaluated for vaginal and rectal pre-exposure prophylaxis against HIV transmission. Because this is a new prevention strategy, we broadly assessed its effects on the mucosa. In MTN-007, a phase-1, randomized, double-blinded rectal microbicide trial, we used systems genomics/proteomics to determine the effect of tenofovir 1% gel, nonoxynol-9 2% gel, placebo gel or no treat...

To better evaluate the renal safety profile of tenofovir, we performed a retrospective study of HIV-infected naïve patients starting a first antiretroviral therapy between July 2005 and July 2008, and followed-up for 24 months. On the whole, 324 patients were enrolled: 201 tenofovir-exposed patients were compared with 123 tenofovir-unexposed subjects. In both unadjusted and adjusted analysis, t...

INTRODUCTION Tenofovir-containing regimens have demonstrated potential efficacy as pre-exposure prophylaxis (PrEP) in preventing HIV-1 infection. Transmitted drug resistance mutations associated with tenofovir, specifically the reverse transcriptase (RT) mutation K65R, may impact the effectiveness of PrEP. The worldwide prevalence of transmitted tenofovir resistance in different HIV-1 subtypes ...

INTRODUCTION Tenofovir is a potent nucleotide analogue reverse-transcriptase inhibitor used with other antiretroviral agents for the treatment of human immunodeficiency virus (HIV) infection. Despite the absence of renal toxicity observed in the major clinical trials of tenofovir, several case reports of acute renal failure (ARF) and proximal tubule dysfunction have been described. CASE PRESE...

impact of tenofovir disoproxil fumarate on kidney function: four-year data from the HIV-infected outpatient cohort. Systematic review and meta-analysis: renal safety of tenofovir disoproxil fumarate in HIV-infected patients. renal failure after initiation of tenofovir disoproxil fumarate. et al. Tenofovir-related nephrotoxicity in human immunodefi-ciency virus-infected patients: three cases of ...

background tenofovir disoproxil fumarate (tdf) is a new effective treatment option for patients with chronic hepatitis b (chb). objectives to evaluate tdf efficacy in nucleos(t)ide analogues (nas)-naive iranian patients with chb. patients and methods the na-naive patients received tdf for at least six months. the primary endpoint was the proportion of patients achieving a complete virological r...

INTRODUCTION Tenofovir-based first-line antiretroviral therapy (ART) is recommended globally. To evaluate the impact of its incorporation into the World Health Organization (WHO) guidelines, we examined treatment failure and drug resistance among a cohort of patients on tenofovir-based first-line ART at the Academic Model Providing Access to Healthcare, a large HIV treatment programme in wester...

The Thai Government Pharmaceutical Organization (GPO) has produced a nucleotide reverse transcriptase inhibitor, tenofovir disoproxil fumarate (Tenofovir GPO300). No clinical trial to date has compared plasma tenofovir concentrations, renal function, and treatment responses in HIV-infected patients who received Teno- fovir GPO300 versus Viread (original tenofovir) as part of an antiretroviral r...