نتایج جستجو برای: temperature sensitive hemagglutinin tsh
تعداد نتایج: 730518 فیلتر نتایج به سال:
1. Daily fluctuations in the plasma concentrations of thyroid stimulating hormone (TSH) and growth hormone (GH) have been studied in six normal males by using a 24 h continuous blood-sampling technique and a highly sensitive and specific radioimmunoassay for TSH. 2. In all subjects the plasma concentrations of the two hormones were increased at night. The TSH concentrations rose approx. 2 h bef...
Newborn screening (NS) for congenital hypothyroidism (CH) is one of the major achievements in preventive medicine. Most neonates born with CH have normal appearance and no detectable physical signs. Hypothyroidism in the newborn period is almost always overlooked, and delayed diagnosis leads to the most severe outcome of CH, mental retardation, emphasizing the importance of NS. Blood spot thyro...
In Madin-Darby canine kidney (MDCK) cells (a polarized epithelial cell line) infected with influenza virus, the hemagglutinin behaves as an apical plasma membrane glycoprotein. To determine biochemically the domain on the plasma membrane, apical or basolateral, where newly synthesized hemagglutinin first appears, cells were cultured on Millipore filters to make both cell surface domains indepen...
CONTEXT The regulation of TSH bioactivity in humans is not completely understood. OBJECTIVE The aim of the study was to investigate the role of serum thyroid hormones in regulating the bioactivity of TSH. DESIGN We determined in vitro TSH bioactivity and glycosylation in nine patients (six females and three males, age 41.3 yr) with primary hypothyroidism before and after L-T(4) replacement,...
Few studies have included subjects with the propensity to reach old age in good health, with the aim to disentangle mechanisms contributing to staying healthier for longer. The hypothalamic-pituitary-thyroid (HPT) axis maintains circulating levels of thyroid stimulating hormone (TSH) and thyroid hormone (TH) in an inverse relationship. Greater longevity has been associated with higher TSH and l...
Thyroid-stimulating hormone (TSH) is a sensitive indicator of thyroid function. High and low TSH levels reflect hypothyroidism and hyperthyroidism, respectively. Even within the normal range, small differences in TSH levels, on the order of 0.5-1.0 mU/l, are associated with significant differences in blood pressure, BMI, dyslipidemia, risk of atrial fibrillation and atherosclerosis. Most of the...
Forty-one routine TSH assays were carried out by applying newly developed, highly sensitive TSH RIA (T. Mori, et al., Folia Endocrinol. Jap., 56: 1231, 1980). B/B0 percent of the least standard point (0.156 microU/ml) was consistently lower than B0 and higher than that of 0.31 microU/ml. The distributions of assayed TSH concentrations in 1394 sera revealed that 34.8% of the total were in an und...
Ag. 1. Evaluation of TSH assays based on redefining assay sensitivity as the " lower limit of interassay quantitative measurement " As iMustrated, e.g., the AbbottEtA for TSH has a lower limit of inter-assay quantitative measurement' of0.3-0.4 miflknt unit&anda lowerlimitofnormal of 0.6 milli-int.unit& and thus by our ciltenais a " sensitivi " assay 1. Determination of the " in-house interassay...
TSH concentrations in dried blood samples on filter paper were determined by a conventional enzyme-linked immunosorbent assay (ELISA), used for routine neonatal screening for primary hypothyroidism, and a highly sensitive bioluminescence ELISA (BL-ELISA) using firefly luciferase to examine whether central hypothyroidism and hyperthyroidism can be efficiently detected as cases of primary hypothy...
Thyrotropin or thyroid-stimulating hormone (TSH) is used as a marker for thyroid function. More precise and more sensitive immunoassays are needed to facilitate continuous monitoring of thyroid dysfunctions and to assess the efficacy of the selected therapy and dosage of medication. Moreover, most thyroid diseases are autoimmune diseases making TSH assays very prone to immunoassay interferences...
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