BACKGROUND Dendritic cells (DC) play a key role in initiation and regulation of immune responses. Plasmacytoid DC (pDC), a small subset of DC, characterized as type-I interferon producing cells, are critically involved in anti-viral immune responses, but also mediate tolerance by induction of regulatory T cells (Treg). In this study, we compared the capacity of human pDC and conventional DC (cD...

Using population synthesis tools we create a synthetic Kepler Input Catalogue (KIC) and subject it to the Kepler Stellar Classification Program (SCP) method for determining stellar parameters such as the effective temperature Teff and surface gravity g. We achieve a satisfactory match between the synthetic KIC and the real KIC in the log g versus log Teff diagram, while there is a significant d...

Previous observations of the soft X-ray and EUV region with the Einstein, EXOSAT, and ROSAT satellites have indicated thepresenceof photospheric absorbers inmostDAwhite dwarfs with Teff >∼ 40000K. Several of these objects have now been observed with the Extreme Ultraviolet Explorer (EUVE). Since the detection of individual metal lines is rather difficult with EUVE spectra we chose the well stud...

Using population synthesis tools we create a synthetic Kepler Input Catalogue (KIC) and subject it to the Kepler Stellar Classification Program (SCP) method for determining stellar parameters such as the effective temperature Teff and surface gravity g. We achieve a satisfactory match between the synthetic KIC and the real KIC in the log g versus log Teff diagram, while there is a significant d...

The nonequilibrium dynamics of a binary Lennard-Jones mixture in a simple shear flow is investigated by means of molecular dynamics simulations. The range of temperature T investigated covers both the liquid, supercooled, and glassy states, while the shear rate g covers both the linear and nonlinear regimes of rheology. The results can be interpreted in the context of a nonequilibrium, schemati...

CD28, CTLA-4 and PD-L1, the three identified ligands for CD80/86, are pivotal positive and negative costimulatory molecules that, among other functions, control T cell motility and formation of immune synapse between T cells and antigen-presenting cells (APCs). What remains incompletely understood is how CD28 leads to the activation of effector T cells (Teff) but inhibition of suppression by re...

The objective of this study was to compare summer annuals for fall and winter grazing on irrigated pastures in the Intermountain West. The cool desert areas of this region have short growing seasons (≤120 d) with high daytime temperatures and cool nights resulting in sufficent growing degree days, but impaired production on cool season forages during late summer. Five species were planted in Ca...

PURPOSE Small cell lung cancer (SCLC) possesses high tendency to disseminate. However, SCLC patients with paraneoplastic syndrome mediated by immunity against onconeural antigens remain in limited-stage disease (LD) without distant metastases. Cumulative evidence regulates that a balance between immune and regulatory T (Treg) cells determines the magnitude of immune responses to not only self-a...

Background OX40, a TNFRSF member, is a co-stimulatory molecule expressed on antigen experienced effector T (Teff) and regulatory T (Treg) cells, including infiltrating cells in mouse and human tumors. Activation of OX40 by agonistic antibodies is hypothesized to promote anti-tumor immunity by enhancing Teff activation and inhibiting Treg mediated suppression. We conducted in vitro and in vivo p...

Using photometric selection criteria, and in a final step visual inspection of spectra, we find 65 DQ white dwarfs in the Data Release 4 of the Sloan Digital Sky Survey. 37 of these are new identifications, three more are reclassified DQ from DC, the other 25 have been described as DQ before in the literature. We derive effective temperatures and carbon abundances for 60 of these stars. The res...