purpose: to compare tear secretion values following lasik (laser in situ keratomileusis) and photorefractive keratectomy (prk). methods: patients referred to aban eye clinic (isfahan, iran) for refractive surgery were randomly assigned to lasik or prk. exclusion criteria were contraindications for refractive surgery, usage of topical ocular drugs, dry eye and reoperation. schirmer test was perf...

BACKGROUND Dry eye has shown a marked increase due to visual display terminal (VDT) use. It remains unclear whether reduced blinking while focusing can have a direct deleterious impact on the lacrimal gland function. To address this issue that potentially affects the life quality, we conducted a large-scale epidemiological study of VDT users and an animal study. METHODOLOGY/PRINCIPAL FINDINGS...

This study was designed to explore the influence of long-term corneal contact lens (CL) wearing on the stability and quality of tear film in Qinghai. Thirty subjects with CL over five years and thirty myopia subjects without CL as control were recruited in our study. Basic tear secretion test, tear film break-up time (TBUT), and corneal fluorescein staining were determined. For further evaluati...

Purpose To evaluate the efficacy of topical rapamycin in treating autoimmune dacryoadenitis in a mouse model of Sjögren's syndrome. Methods We developed rapamycin in a poly(ethylene glycol)-distearoyl phosphatidylethanolamine (PEG-DSPE) micelle formulation to maintain solubility. Rapamycin or PEG-DSPE eye drops (vehicle) were administered in a well-established Sjögren's syndrome disease model...

background: the therapeutic administration of 131i for thyroid remnant ablation and for metastases comes up with some adverse effects. this study was conducted to investigate whether single high dose radioiodine therapy affects lacrimal gland functions or not. materials and methods: seventy-eight eyes of 39 patients, who were diagnosed as differentiated thyroid carcinoma, were objectively teste...

Dry eye is highly prevalent worldwide and its incidence is known to increase with age. Several clinical studies have demonstrated reduced tear secretion in older people, indicating that lacrimal gland function decreases gradually with age. It has been reported that Excess caloric intake accelerates the aging process, and increases the risks for age-related diseases. Metabolic syndrome (MetS) is...

BACKGROUND Dry eye is a multifactorial disease characterized by ocular discomfort and visual impairment. Lacrimal gland function has been shown to decrease with aging, a known potent risk factor for dry eye. We have previously found that orally administrated royal jelly (RJ) restored tear secretion in a rat model of dry eye. METHODS AND FINDINGS We examined the effects of RJ oral administrati...

Dry eye syndrome is caused by a reduction in the volume or quality of tears. Here, we show that pituitary adenylate cyclase-activating polypeptide (PACAP)-null mice develop dry eye-like symptoms such as corneal keratinization and tear reduction. PACAP immunoreactivity is co-localized with a neuronal marker, and PACAP receptor (PAC1-R) immunoreactivity is observed in mouse infraorbital lacrimal ...

Dry eye syndrome (DES), a multifactorial disease of the tears and ocular surface, is one of the most common ocular disorders. Tear film contains ocular mucins and is essential for maintaining the homeostasis of the wet ocular surface. Since there are a limited number of clinical options for the treatment of DES, additional novel treatments are needed to improve the clinical results. In this stu...

Dry eye disease is a disorder in tear film physiology, which leads to various abnormal states of ocular surface cells. In the present study, we evaluated the potential usefulness of orally applied maqui berry (Aristotelia chilensis) extract and the constituent anthocyanin as a preventative intervention in dry eye. Tear secretion capacity was evaluated following the oral administration of maqui ...