Pretargeted PET imaging has emerged as an effective two-step in vivo approach that combines the superior affinity and selectivity of antibodies with the rapid pharmacokinetics and favorable dosimetry of smaller molecules radiolabeled with short-lived radionuclides. This approach can be based on the bioorthogonal inverse-electron-demand Diels–Alder (IEDDA) reaction between tetrazines and trans-c...

In the manganite Nd0.5Ca0.5MnO3, charge ordering occurs at much higher temperature than the antiferromagnetic order (TCO = 250K, TN = 160K). the magnetic behavior of the phase TN < T < TCO is puzzling: its magnetization and susceptibility are typical of an antiferromagnet while no magnetic order is detected by neutron diffraction.We have undertaken an extensive study of the cristallographic, el...

Here, we report a method to specifically bind liposomal radiopharmaceuticals to a CoCrMo alloy, which can be used in arterial stents, via an irreversible inverse electron-demand Diels-Alder reaction. Inspired by recent accomplishments in pre-targeted imaging using tetrazine-trans-cyclooctene click chemistry, we synthesized 89Zr-labeled trans-cyclooctene-functionalized liposomal nanoparticles, w...

LP-CVD ZnO has been developed at IMT as front TCO for amorphous silicon p-i-n single-junction and “micromorph” (microcrystalline/amorphous silicon) tandem solar cells. In comparison with SnO2 (Asahi type U), ZnO demonstrates superior light-trapping behaviour. Applying the monolithic series connection by laser-scribing, both for amorphous single-junction and micromorph tandem cells, modules have...

Tuberculosis cutis orificialis (TCO) is a rare manifestation of cutaneous tuberculosis that is caused by auto-inoculation of mycobacteria in patients with advanced internal tuberculosis. TCO occurs in oral, perianal, or genital mucosa and adjacent skin. The tongue is the most frequently affected site, but the perianal area can also be affected. A 39-year-old male presented with a 4-month histor...

Described herein is interfacial bioorthogonal cross-linking, the use of bioorthogonal chemistry to create and pattern biomaterials through diffusion-controlled gelation at the liquid-gel interface. The basis is a rapid (k2 284000 M-1 s-1) reaction between strained trans-cyclooctene (TCO) and tetrazine (Tz) derivatives. Syringe delivery of Tz-functionalized hyaluronic acid (HA-Tz) to a bath of b...

this paper addresses the mixed integer reliability redundancy allocation problems to determine simultaneous allocation of optimal reliability and redundancy level of components based on three objective goals. system engineering principles suggest that the best design is the design that maximizes the system operational effectiveness and at the same time minimizes the total cost of ownership (tco...

Single compartmental spherules of various lipid constituents (vesicles), enclosing (99m)TcO(4) (-) as a radioactive marker, were injected intravenously into C(3)H mice, and the distribution of radioactivity was studied. About 25% of the administered radioactivity was present in the liver 5 min and 30 min after the injection of vesicles composed of phosphatidylcholine and gangliosides, which wer...

UNLABELLED Current pretargeting systems use noncovalent biologic interactions, which are prone to immunogenicity. We previously developed a novel approach based on the bioorthogonal reaction between a radiolabeled tetrazine and an antibody-conjugated trans-cyclooctene (TCO). However, the tumor-to-blood ratio was low due to reaction with freely circulating antibody-TCO. METHODS Here we develop...