BACKGROUND The combination of propofol-remifentanil for procedural deep sedation in spontaneously breathing patients is characterized by the frequent incidence of side effects, especially respiratory depression. These side effects may be due to either the drug combination or the drug delivery technique. Target-controlled infusion (TCI) might optimize drug delivery. In this prospective, randomiz...

BACKGROUND The imidazoquinoline derivate imiquimod induces inflammatory responses and protection against transplanted tumors when applied to the skin in combination with a cognate peptide epitope (transcutaneous immunization, TCI). Here we investigated the role of regulatory T cells (T(reg)) and the suppressive cytokine IL-10 in restricting TCI-induced cytotoxic T lymphocyte (CTL) responses. ...

BACKGROUND Transcutaneous immunization (TCI) is a novel vaccination strategy, which is expected to have therapeutic applications. However, to develop effective TCI systems, a simple, non-invasive and safe transdermal formulation is required. This study developed a novel TCI system utilizing the co-administration of a liposoluble absorption enhancer, propylene glycol monocaprylate (PGMC) and hyd...

BACKGROUND We investigated how one pharmacokinetic (PK) model differed in prediction of plasma (C(p)) and effect-site concentration (C(eff)) using a reproducing simulation of target-controlled infusion (TCI) with another PK model of propofol. METHODS Sixty female patients were randomly assigned to TCI using Marsh PK (Group M) and TCI using Schnider PK (Group S) targeting 6.0 µg/ml of C(p) of ...

Implementation of enterprise resource planning (ERPs) systems is probably the most laborious and rather costly part of the ERP system life-cycle. In the paper, we provide a percentage structure of total cost of implementation (TCI) from the end-user company’s perspective. Having a grasp over TCI should be of interest to companies planning to implement ERP systems, since literature suggests that...

BACKGROUND & OBJECTIVE Aminoglycoside antibiotics, especially gentamicin, are widely used in suspected Gram-negative infections in India. Therapeutic drug monitoring is not commonly used for this drug in our population. We evaluated the target concentration intervention (TCI) strategy of gentamicin therapy in a predominantly malnourished patient population with lower respiratory tract infection...

Drought is a major problematic phenomenon for the mostly semi-arid country of Iran. The north centralregions of Iran (north of Esfahan and Ghom province) have suffered from severe droughts several times duringthe last three decades. The frequent occurrence of drought in these regions is due to low and inconsistentprecipitation, abnormally high temperatures, increases in surface albedo and evapo...

Drought is a major environmental disaster in many parts of the world. Knowledge about the timing, severity and extentof drought can aid planning and decision-making. Drought indices derived from in-situ meteorological data have coarsespatial and temporal resolutions, thus, obtaining a real-time drought condition over a large area is difficult. This studyused advanced very high resolution radiom...

The purpose of this study was to examine the effects of an exercise intervention on the total caloric intake (TCI) of breast cancer patients undergoing treatment. A secondary purpose was to determine whether or not a relationship existed between changes in TCI, body fat composition (%BF), and fatigue during the study, which lasted 6 months. Twenty females recently diagnosed with breast cancer, ...