Extracellular vesicles (EVs) have been found to be secreted by various cells and work as mediator communicate between transport of cellular components. Previously, we serum EVs (sEVs) contained Helicobacter pylori-derived peptide associated with an immune recognition resulting skin manifestation. Recent study proposed microbial alteration dysbiosis contribute atopic dermatitis (AD) pathogenesis...

Applying highly sensitive modern immune profiling techniques to the blood or inflamed tissue of auto-immune patients with one of the common T-cell mediated diseases fails to detect large clonal expansions or other signs of a dysregulated immune system. Additionally, these new methods have shown that self-reactive Tcells are found in the periphery (and are not completely negatively selected in t...

Despite successful suppression of viral replication by antiretroviral drugs there is no significant increase in the number peripheral CD4 + T lymphocytes some HIV-infected patients (immune nonresponse to therapy). One crucial factors for immunodeficiency aggravation immune activation developing response bacterial products entry into bloodstream through damaged intestinal barrier. Additionally, ...

Glutamic acid decarboxylase (GAD)65 is an early and important antigen in both human diabetes mellitus and the nonobese diabetic (NOD) mouse. However, the exact role of GAD65-specific T cells in diabetes pathogenesis is unclear. T cell responses to GAD65 occur early in diabetes pathogenesis, yet only one GAD65-specific T cell clone of many identified can transfer diabetes. We have generated tran...

Psoriasis is a frequent autoimmune chronic skin disease differentiated by T-Cells agreeable hyperproliferation of epidermal Keratinocytes. The feature of TCells held up Psoriatic scratches is the epidermal penetration of basically oligoclonal CD8 T-Cells and also of CD4 T-Cells in the dermis. Psoriatic lesions are sharply distinguished, red and enlarged scratches together with whitish silver sc...

Interleukin-2 (IL-2) has been shown to possess antitumor activity in numerous preclinical and clinical studies. However, the short half-life of recombinant IL-2 protein in serum requires repeated high-dose injections, resulting in severe side effects. Although adenovirus-mediated IL-2 gene therapy has shown antitumor efficacy, the host antibody response to adenoviral particles and potential bio...

Sanglifehrin A (SFA) is a cyclophilin-binding immunosuppressant but the immunobiology of action is poorly understood. We and others have reported that SFA inhibits IL-12 production and antigen uptake in dendritic cells (DC) and exhibits lower activity against lymphocytes. Here we show that SFA suppresses DC chemokine production and migration. Gene expression analysis and subsequent protein leve...

Abstract: Arsenic trioxide (As2O3) has cytotoxic effects on several cancer cell lines. However, the molecular mechanisms of action remain to be elucidated. Hence, the aim of the present study was to evaluate the cytotoxicity and genotoxicity induced by As2O3 in a human Jurkat T-cell line using the MTT [3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] and alkaline single cell gel e...

Interleukin-2 (IL-2) has been shown to possess antitumor activity in numerous preclinical and clinical studies. However, the short half-life of recombinant IL-2 protein in serum requires repeated high-dose injections, resulting in severe side effects. Although adenovirus-mediated IL-2 gene therapy has shown antitumor efficacy, the host antibody response to adenoviral particles and potential bio...

The graft-vs-tumor effect is an important part of the curative potential of allogeneic transplantation. We characterized the effect of transplanted donor mononuclear cells on relapse- and event-free survival after allogeneic bone marrow transplantation (BMT). We studied 113 consecutive patients with hematologic malignancies who received non-T-cell-depleted BMT from human leukocyte antigen (HLA)...