The mechanisms that lead to loss of MHC class I expression in different types of tumors are not yet fully known. Accordingly, we studied colorectal carcinomas to elucidate the specific mechanisms of evasion of the T-cell immune response. We selected tumors with total loss of MHC class I expression and studied 124 colorectal carcinomas with immunohistochemical staining and anti-HLA monoclonal an...

Destruction of cancer cells by cytotoxic T lymphocytes depends on immunogenic tumor peptides generated by proteasomes and presented by human leukocyte antigen (HLA) molecules. Functional differences arising from alleles of immunoproteasome subunits have not been recognized so far. We analyzed the genetic polymorphism of the immunoproteasome subunits LMP2 and LMP7 and of the transporters associa...

Letm(y)=∑j=1yj/n and s(y)= √ m(y2)−m2(y) be themean and the standard deviation of the components of the vector y = (y1, y2, . . . , yn−1, yn), where yq = (y 1 , y 2 , . . . , y n−1, y n) with q a positive integer. Here, we prove that if y ≥ 0, then m(y2p) + (1/√n− 1)s(y2p) ≤ √ m(y2 ) + (1/ √ n− 1)s(y2 ) for p = 0,1,2, . . . . The equality holds if and only if the (n − 1) largest components of y...

Example 0.1. Let f : X → P be a non-isotrivial semistable family of Abelian varieties of dimension g over the complex line, then: i. s = #{ singular fibres } ≥ 4. ii. s = 4 if and only if f is isogenous to E ×P1 E ×P1 · · · ×P1 E where E → P is one of the 6 modular families of elliptic curves, smooth over P \ {y1, . . . , y4} for some distinct points y1, . . . , y4 ∈ P (as described in [Beauvil...

Major histocompatibility class I deficiency, due to genetic lesions in TAP1, TAP2, TAPBP, or B2M, manifests with recurrent sinopulmonary infections and granulomatous skin ulceration, is predominately treated antimicrobial prophylaxis chest physiotherapy. One previous report of hematopoietic stem cell transplantation has been described the literature, demonstrating cure immune defect without sig...