MOHAMED ABO EL-ENEN, MOHAMED GABER, * MOHAMED SAMY Urology and *Radiology Departments, Tanta University, Tanta, Egypt. Aim of the work: Is to investigate the role and effect of tamsulosin as adjuvant therapy in treatment of symptomatic renal calculi after extracorporeal shock wave lithotripsy (ESWL). Patients and Methods: A total 120 patients with single renal pelvic stone <20mm subjected for E...

OBJECTIVE To assess the additive effect of sildenafil citrate to tamsulosin in the treatment of lower urinary tract symptoms due to benign prostatic hyperplasia (LUTS/BPH) in men with or without erectile dysfunction (ED). PATIENTS AND METHODS In all, 150 men with untreated LUTS/BPH with or without ED were randomised to receive sildenafil 25 mg once daily (OD) or placebo OD (night time) combin...

OBJECTIVE To determine whether severe intraoperative floppy iris syndrome (IFIS) is more or equally likely with tamsulosin or alfuzosin. DESIGN Prospective, masked, multicenter, cross-sectional study. PARTICIPANTS AND CONTROLS Consecutive patients taking systemic tamsulosin or alfuzosin and scheduled for routine cataract surgery (case group) and patients with no history of systemic α1-antag...

OBJECTIVE To analyze the clinical effect of tamsulosin and Solifenacin in the treatment of benign prostatic hyperplasia in combination with overactive bladder and its safety. Another objective was to investigate the clinical effect and safety of mega dose of tamsulosin in the treatment of benign prostatic hyperplasia in combination with overactive bladder. METHODS One hundred and twenty-four ...

Objectives: This study was performed to assess the effects of α1A adrenoceptor antagonists on urethral perfusion pressure (UPP) and their therapeutic potential for female bladder outlet obstruction (BOO). Methods: A cannula was inserted into the femoral arteries of female rats to administer tamsulosin (treatment I), doxazosin (treatment II) or phentolamin (treatment III) and to monitor systemic...

three patients developed hyperglycaemia during tamsulosin use. all patients had diabetes and recovered after withdrawal. a pharmacological mechanism for this adverse drug reaction is suggested: stimulation of the α1-receptor is one of the insulin-independent pathways for glucose uptake, hence inhibition might increase plasma glucose concentrations. Physicians should be aware of hyperglycaemia a...

PURPOSE To examine the effects on erectile function of concomitant treatment with an alpha-blocker (tamsulosin) and an antimuscarinic agent (solifenacin) in patients with lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH). MATERIALS AND METHODS Fifty-seven male patients with LUTS/BPH were assessed for the degree of LUTS and erectile function. In group 1 (tamsulosin) and gr...

OBJECTIVES We examined the effects of alpha1-adrenoceptor antagonist (tamsulosin hydrochloride) and antimuscarinic agent (solifenacin succinate) alone or in combination on the urinary adenosine triphosphate (ATP) level and cystometric parameters before and after bladder stimulation. METHODS Female rats were administered tamsulosin hydrochloride (0.5 or 3 µg/kg/h) and/or solifenacin succinate ...

Obstructive sleep apnea (OSA) is characterized by repeated involuntary closure of the pharyngeal airspace during sleep. Normal activity of the genioglossus (GG) muscle is important in maintaining airway patency, and inhibition of GG activity can contribute to airway closure. Neurons in the hypoglossal motor nucleus (HMN) regulate GG activity. Adrenergic tone is an important regulator of HMN neu...

Since intraoperative floppy iris syndrome (IFIS) was first described in 2005, its association with the systemic alpha-1 adrenergic antagonist, tamsulosin (Flomax®, Boehringer-Ingelheim Pharmaceuticals, Inc., Ridgefield, CT), has become well established [1-7]. The clinical manifestations of IFIS complicating cataract surgery are poor preoperative pupil dilation, iris billowing and prolapse, and ...