نتایج جستجو برای: tail immersion method

تعداد نتایج: 1687010  

2010
Abbas Ahmadi Mohsen Khalili Ramin Hajikhani Leila Barghi Farnaz Mihandoust

Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and ketamine (2-O-chlorophenyl-2-methylaminocyclohexan, II) have shown analgesic effects. Some of its derivatives were synthesized and their biological properties have been studied. In this study, a new derivative of PCP, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, PCP-OCH3-tetralyl, III) was synthesized and the acute thermal pain of...

Journal: :European journal of pharmacology 2010
Esther Gramage Gonzalo Herradon

Pleiotrophin (PTN) is a growth factor that exhibits neurotrophic actions and is upregulated at sites of nerve injury. Upregulation of PTN levels in injured dorsal root ganglion correlates with decreased mechanical allodynia and faster recovery from Chronic Constriction Injury of the rat sciatic nerve. Despite the evidence pointing to a role of PTN in the development of chronic pain, the role of...

Journal: :journal of dental research, dental clinics, dental prospects 0
fahimeh hamedi rad tabriz university of medical sciences tahereh ghaffari tabriz university of medical sciences, iran sayed hamed safavi

background and aims. the most common method for alginate impression disinfection is spraying it by disinfecting agents, but some studies have shown that these impressions can be immersed, too. the aim of this study was to evaluate the dimensional stability of alginate impressions following disinfecting by spray and immersion methods. materials and methods. four common disinfecting agents (sodiu...

Journal: :The Malaysian journal of medical sciences : MJMS 2015
Md Mominur Rahman Muhammad Erfan Uddin Abu Mohammed Taufiqual Islam Md Ashraf Uddin Chowdhury Md Atiar Rahman

BACKGROUND Various parts of Pandanus foetidus Roxb. are used as traditional medicines. However, scientific reports concerning the effect of this plant on central nervous system (CNS) depression and analgesia are unavailable. This study investigated the CNS depressant and antinociceptive effects of Pandanus foetidus leaf extracts in a rodent model. METHODS The sedative and anxiolytic activitie...

2011
Pritesh Ranjan Dash Mahmuda Nasrin Moni Rani Saha

This study was aimed to investigate analgesic and neuropharmacological actions of the methanolic extract of rhizomes of Hedychium coronarium. The analgesic activity was evaluated for its central and peripheral pharmacological actions using tail immersion method and acetic acid-induced writhing test in mice respectively. The extract, at the doses of 100, 200 and 400 mg/kg body weight, produced a...

Journal: :Asian Pacific journal of tropical biomedicine 2011
Dnyaneshwar J Taur Maruti G Waghmare Rajendra S Bandal Ravindra Y Patil

OBJECTIVE To evaluate the antinociceptive activity of the methanol extract of Ricinus communis leaves (MRCL). METHODS Antinociceptive activity was evaluated using acetic acid induced writhing test, formalin induced paw licking and tail immersion method in mice at doses of 100, 125 and 150 mg/kg bw. RESULTS The results indicated that MRCL exhibited considerable antinociceptive activity again...

Journal: :European review for medical and pharmacological sciences 2015
K R Savic Vujovic S Vuckovic D Srebro B Medic R Stojanovic C Vucetic M Prostran

OBJECTIVE Magnesium is an endogenous voltage-dependent NMDA receptor-channel blocker and ketamine is a non-competitive NMDA receptor antagonist. Magnesium may potentiate the effect of ketamine in analgesia and anaesthesia, but may also interact in an opposing manner. This study aimed at evaluating type of the interaction between magnesium sulphate and ketamine administered systemically in rats ...

2017
Sumaira Ansari Sadia Arif Nousheen Mushtaq Ahsaan Ahmed Shamim Akhtar Rabya Munawar Huma Naseem Sadia Meer Zafar Saied Saify Muhammad Arif

In present study, some 4-piperidinopiperidine (PP) and 4-amino methylpiperidine (AMP) derivatives (PP1-3 and AMP4-9) have been synthesized to explore their analgesic potential. Activity of compounds evaluated by in-vivo thermal (tail immersion) method produced significant analgesia at different doses. Docking results explained good binding affinity of synthesized derivatives and potential inter...

تاجمیر عالی, شمایل, سترکی, محبوبه, هوشمندی, زهرا,

Background and Objective: Due to the numerous side effects of synthetic analgesics, attention has been paid to find new analgesic agents with fewer side effects. This study aimed to evaluate the analgesic properties of Satureja bachtiarica essential oil in mice. Materials and Methods: In this study, eighty male NMRI mice were randomly assigned to 5 groups including a control group, groups rece...

تمجید شبستری, شبنم, معتمد, نیما, کریمی کیا, مریم,

Background and Objective: Due to the numerous side effects of synthetic analgesics, attention has been paid to find new analgesic agents with fewer side effects. This study aimed to evaluate the analgesic properties of Satureja bachtiarica essential oil in mice. Materials and Methods: In this study, eighty male NMRI mice were randomly assigned to 5 groups including a control group, groups rece...

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