Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and ketamine (2-O-chlorophenyl-2-methylaminocyclohexan, II) have shown analgesic effects. Some of its derivatives were synthesized and their biological properties have been studied. In this study, a new derivative of PCP, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, PCP-OCH3-tetralyl, III) was synthesized and the acute thermal pain of...

Pleiotrophin (PTN) is a growth factor that exhibits neurotrophic actions and is upregulated at sites of nerve injury. Upregulation of PTN levels in injured dorsal root ganglion correlates with decreased mechanical allodynia and faster recovery from Chronic Constriction Injury of the rat sciatic nerve. Despite the evidence pointing to a role of PTN in the development of chronic pain, the role of...

background and aims. the most common method for alginate impression disinfection is spraying it by disinfecting agents, but some studies have shown that these impressions can be immersed, too. the aim of this study was to evaluate the dimensional stability of alginate impressions following disinfecting by spray and immersion methods. materials and methods. four common disinfecting agents (sodiu...

BACKGROUND Various parts of Pandanus foetidus Roxb. are used as traditional medicines. However, scientific reports concerning the effect of this plant on central nervous system (CNS) depression and analgesia are unavailable. This study investigated the CNS depressant and antinociceptive effects of Pandanus foetidus leaf extracts in a rodent model. METHODS The sedative and anxiolytic activitie...

This study was aimed to investigate analgesic and neuropharmacological actions of the methanolic extract of rhizomes of Hedychium coronarium. The analgesic activity was evaluated for its central and peripheral pharmacological actions using tail immersion method and acetic acid-induced writhing test in mice respectively. The extract, at the doses of 100, 200 and 400 mg/kg body weight, produced a...

OBJECTIVE To evaluate the antinociceptive activity of the methanol extract of Ricinus communis leaves (MRCL). METHODS Antinociceptive activity was evaluated using acetic acid induced writhing test, formalin induced paw licking and tail immersion method in mice at doses of 100, 125 and 150 mg/kg bw. RESULTS The results indicated that MRCL exhibited considerable antinociceptive activity again...

OBJECTIVE Magnesium is an endogenous voltage-dependent NMDA receptor-channel blocker and ketamine is a non-competitive NMDA receptor antagonist. Magnesium may potentiate the effect of ketamine in analgesia and anaesthesia, but may also interact in an opposing manner. This study aimed at evaluating type of the interaction between magnesium sulphate and ketamine administered systemically in rats ...

In present study, some 4-piperidinopiperidine (PP) and 4-amino methylpiperidine (AMP) derivatives (PP1-3 and AMP4-9) have been synthesized to explore their analgesic potential. Activity of compounds evaluated by in-vivo thermal (tail immersion) method produced significant analgesia at different doses. Docking results explained good binding affinity of synthesized derivatives and potential inter...