Abstract Among other electrophysiological biomarkers, power reduction in the alpha frequency band (8-12 Hz) is characteristic of Alzheimer’s Disease (AD). Restoring this could help improve performance related functional networks and cognitive state AD patients. Transcranial alternate current stimulation (tACS) stands as a promising tool regard, given its capacity to entrain neural activity at p...

to the gamma band (Varela et al., 2001). This resonance-like interplay between externally applied and internally generated regional oscillatory activity may prove a powerful approach to manipulate brain activity. So far, investigations of tACS effects on cognitive performance have been limited to visual and somatosensory perception (Feurra et al., 2011b), and motor control (Pogosyan et al., 200...

PURPOSE OF REVIEW This article covers the clinical manifestations and differential diagnosis of the trigeminal autonomic cephalalgias (TACs). RECENT FINDINGS TACs comprise a subgroup of primary headache disorders presenting with lateralized, often severe, pain accompanied by cranial autonomic features. The key syndromes are cluster headache, paroxysmal hemicrania, short-lasting unilateral neu...

We walk together, we watch together, we win together: Interpersonally coordinated actions are omnipresent in everyday life, yet the associated neural mechanisms are not well understood. Available evidence suggests that the synchronization of oscillatory activity across brains may provide a mechanism for the temporal alignment of actions between two or more individuals. In an attempt to provide ...

We show how dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data can constrain a compartmental model for analyzing dynamic positron emission tomography (PET) data. We first develop the theory that enables the use of DCE-MRI data to separate whole tissue time activity curves (TACs) available from dynamic PET data into individual TACs associated with the blood space, the extravascu...

Transcranial Direct Current Stimulation (tDCS) has been widely investigated for its potential to enhance cognition, and in particular working memory, however to date standard approaches to stimulation have shown only modest effects. Alternative, more specialised, forms of current delivery may be better suited to cognitive enhancement. One such method is transcranial Alternating Current Stimulat...

The study aimed to explore the role of the fronto-parietal brain network in working memory function--in temporary storage and manipulation of information. In a single blind sham controlled experiment 36 respondents solved different working memory tasks after theta transcranial alternating current stimulation (tACS) was applied to left frontal, left parietal and right parietal areas. Both verum ...

Background. Transcranial alternating current stimulation (tACS) is a relatively recent method suited to noninvasively modulate brain oscillations. Technically the method is similar but not identical to transcranial direct current stimulation (tDCS). While decades of research in animals and humans has revealed the main physiological mechanisms of tDCS, less is known about the physiological mecha...

BACKGROUND Transcranial alternating current stimulation (tACS) is a non-invasive brain stimulation modality that may modulate cognition by enhancing endogenous neocortical oscillations by application of sine-wave electric fields. Yet, the role of endogenous network activity in enabling and shaping the effects of tACS has remained unclear. OBJECTIVE We combined optogenetic stimulation and mult...

Transcranial alternating current stimulation (tACS) has until now mostly been administered as an alternating sinusoidal wave. Despite modern tACS stimulators being able to deliver alternating current with any arbitrary shape there has been no systematic exploration into the relative benefits of different waveforms. As tACS is a relatively new technique there is a huge parameter space of unexplo...