نتایج جستجو برای: tac

تعداد نتایج: 5005  

2015
Kiyoshi Migita Yukihiro Akeda Manabu Akazawa Shigeto Tohma Fuminori Hirano Haruko Ideguchi Ryutaro Matsumura Eiichi Suematsu Tomoya Miyamura Shunsuke Mori Takahiro Fukui Yasumori Izumi Nozomi Iwanaga Hiroshi Tsutani Kouichirou Saisyo Takao Yamanaka Shiro Ohshima Takao Sugiyama Yojiro Kawabe Masao Katayama Yasuo Suenaga Akira Okamoto Hisaji Ohshima Yasumasa Okada Kenji Ichikawa Shigeru Yoshizawa Kenji Kawakami Toshihiro Matsui Hiroshi Furukawa Kazunori Oishi

INTRODUCTION In rheumatoid arthritis (RA) patients receiving immunosuppressive treatments, vaccination against Streptococcus pneumoniae is recommended. The objective of the study was to evaluate the effects of tacrolimus (TAC) on immune response following administration of a 23-valent pneumococcal polysaccharide vaccine (PPSV23) in patients with established RA. METHODS Patients with RA (n = 1...

2016
Sun Woo Lim Long Jin Jian Jin Chul Woo Yang

Growing evidence suggests that GLP-1 protects beta cells against various cellular injuries by modulating autophagy. In this study, we examined whether exendin-4 (Ex-4), a GLP-1 analog, had preventive effects on tacrolimus (Tac)-induced beta cell injury by improving autophagy clearance. Rats with Tac-induced diabetes mellitus exhibited increased autophagy-associated protein expression, light cha...

Journal: :In vivo 2005
Tatsuhiko Sako Yoshifumi Nakayama Noritaka Minagawa Yuzuru Inoue Koji Onitsuka Takefumi Katsuki Yosuke Tsurudome Kazunori Shibao Keiji Hirata Naoki Nagata Shinji Ohie Kimitoshi Kohno Hideaki Itoh

BACKGROUND 4-[3,5-Bis (trimethylsilyl) benzamido] benzoic acid (TAC-101) is a novel retinobenzoic acid derivative, which has a specific binding affinity to the retinoic acid receptors (RAR)-alpha and -beta. Apoptotic induction by TAC-101 was investigated using a rat hepatic metastatic model of rat RCN-9 colon cancer cells in vivo and FACScan analysis with the DLD-1 human colon cancer cell line ...

Journal: :American journal of physiology. Heart and circulatory physiology 2013
Ayako Takahashi Masanori Asakura Shin Ito Kyung-Duk Min Kazuhiro Shindo Yi Yan Yulin Liao Satoru Yamazaki Shoji Sanada Yoshihiro Asano Hatsue Ishibashi-Ueda Seiji Takashima Tetsuo Minamino Hiroshi Asanuma Naoki Mochizuki Masafumi Kitakaze

Incretin hormones, including glucagon-like peptide-1 (GLP-1), a target for diabetes mellitus (DM) treatment, are associated with cardioprotection. As dipeptidyl-peptidase IV (DPP-IV) inhibition increases plasma GLP-1 levels in vivo, we investigated the cardioprotective effects of the DPP-IV inhibitor vildagliptin in a murine heart failure (HF) model. We induced transverse aortic constriction (T...

2012
Satomi Kobayashi Kentaro Murakami Satoshi Sasaki Kazuhiro Uenishi Mitsuyo Yamasaki Hitomi Hayabuchi Toshinao Goda Jun Oka Keiko Baba Kazuko Ohki Reiko Watanabe Yoshiko Sugiyamama

BACKGROUND The association between dietary total antioxidant capacity (TAC) from different assays and serum C-reactive protein (CRP) has not been assessed in non-Western populations. We examined the association between dietary TAC and serum CRP concentration in young Japanese women using different four TAC assays. METHODS The subjects were 443 young Japanese women aged 18-22 years. Dietary TA...

Journal: :Clinical journal of the American Society of Nephrology : CJASN 2007
Thomas E Burroughs Krista L Lentine Steve K Takemoto Jason Swindle Gerardo Machnicki Karen Hardinger Daniel C Brennan William D Irish Mark A Schnitzler

Risk for new-onset diabetes (NOD) after renal transplantation is higher with tacrolimus (Tac) than with cyclosporine (CsA), but the extent to which the diabetogenic effect of Tac is dosage dependent or steroid dependent remains uncertain. Patients who received a transplant between 1995 and 2002 were drawn from the United Network for Organ Sharing registry and prescription records and NOD diagno...

2006
Vedran Podobnik Ana Petric Gordan Jezic

The Trading Agent Competition (TAC) is an international forum which promotes high-quality research regarding the trading agent problem. One of the TAC competitive scenarios is Supply Chain Management (SCM) where six agents compete by buying components, assembling PCs from these components and selling the manufactured PCs to customers. The idea of TAC SCM is the development of agent-based archit...

2013
Jianxun Wang Jianxiang Xu Qianwen Wang Robert E. Brainard Lewis J. Watson Steven P. Jones Paul N. Epstein

This study was designed to test whether reduced levels of cardiac fructose-2,6-bisphosphate (F-2,6-P(2)) exacerbates cardiac damage in response to pressure overload. F-2,6-P(2) is a positive regulator of the glycolytic enzyme phosphofructokinase. Normal and Mb transgenic mice were subject to transverse aortic constriction (TAC) or sham surgery. Mb transgenic mice have reduced F-2,6-P(2) levels,...

Journal: :Journal of cell science 2007
Jean-Michel Bellanger J Clayton Carter Jennifer B Phillips Coralie Canard Bruce Bowerman Pierre Gönczy

The early Caenorhabditis elegans embryo is well suited for investigating microtubule-dependent cell division processes. In the one-cell stage, the XMAP215 homologue ZYG-9, associated with the TACC protein TAC-1, promotes microtubule growth during interphase and mitosis, whereas the doublecortin domain protein ZYG-8 is required for anaphase spindle positioning. How ZYG-9, TAC-1 and ZYG-8 togethe...

2017
Paul Dorbec Mehdi Mhalla

In this paper, we propose a Quantum variation of combinatorial games, generalizing the Quantum Tic-Tac-Toe proposed by Allan Goff [2006]. A Combinatorial Game is a two-player game with no chance and no hidden information, such as Go or Chess. In this paper, we consider the possibility of playing superpositions of moves in such games. We propose different rulesets depending on when superposed mo...

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