The reversible inhibition of acetylcholinesterase (AChE) by 4,4'-bipyridine (BP) was measured with acetylthiocholine as substrate. The enzyme/inhibitor dissociation constant for binding of BP to the catalytic site was Ka = 1.0 mM and the non-competitive dissociation constant for binding to an allosteric site was K, = = 9.0 mM. BP protected AChE against phosphylation by sarin, soman, tabun and V...

This paper discusses the toxicity and antidotal effects of 32 compounds. Screening studies have shown that these compounds combined with atropine are effective antidotes against the organophosphate nerve agents Tabun and/or Soman, having a therapeutic factor equal or greater than 2.0 when tested in mice or rats. We analysed the results of these studies, and recommend that these compounds should...

Acetyl cholinesterase (AChE) and butyryl cholinesterase (BChE) are two known enzymes in the body with ability to hydrolyze acetylcholine. While AChE plays crucial role in acetylcholine mediated neurotransmission, BChE is secreted from livers to plasma and biological role of the enzyme is not fully understood [1]. The both cholinesterases are very sensitive to inhibition by nerve agents such as ...

Imidazo[1,2-a] pyridine-based two probes with different substituents containing oxime and hydroxyl functional groups were synthesised evaluated for detection of tabun nerve agent simulant diethylcyanophosphonate (DCNP). The nucleophile group present on both the can be rapidly phosphorylated by DCNP through a nucleophilic substitution reaction. fluorescent reacting underwent fluorescence OFF, wh...

In this work, the effect of ligand's length on interaction energy of six oximes, A [2-(hydroxyimino)-N-((1-(2-(2-((hydroxyimino)methyl)-1H-imidazol-1-yl)ethyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide], B [2-(hydroxyimino)-N-((1-(3-(2-((hydroxyimino)methyl)-1H-imidazol-1-yl)propyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide], C [2-(hydroxyimino)-N-((1-(4-(2-((hydroxyimino)methyl)-1H-imidazol-1-yl)but...

Üçağızlı II Mağarası Hatay İli’nin Akdeniz kıyısında yer alan Orta Paleolitik Dönem’e ait bir yerleşim alanıdır. Mağara, kısmen yıkılmıştır ve uranyum serisi yöntemi ile 75,000 42,000 yıl öncesine tarihlendirilmiştir. Bu çalışmada, 2020 yılı kazı çalışmalarında Büst tabakasından elde edilen faunal kalıntılar yontmataş endüstrisi incelenmiştir. tabakasında Akdeniz’in tipik kalıntıları saptanmış,...

The enzyme group-VIIA phospholipase A2 (gVIIA-PLA2) is bound to lipoproteins in human blood and hydrolyzes the ester bond at the sn-2 position of phospholipid substrates with a short sn-2 chain. The enzyme belongs to a serine hydrolase superfamily of enzymes, which react with organophosphorus (OP) nerve agents. OPs ultimately exert their toxicity by inhibiting human acetycholinesterase at nerve...