The paper studies the compressibility of directly compressible tableting materials with dry binders, spray-dried lactose and microcrystalline cellulose, and glyceryl dibehenate at various concentrations. Compressibility was evaluated by means of the energy profile of compression and tensile strength of tablets. Release rate of the active ingredient, salicylic acid, from the tablets was also exa...

Famotidine Form B P. P. Upadhyay, M. K. Mishra, U. Ramamurty, A. D. Bond University of Copenhagen, Indian Institute of Science, University of Cambridge Purpose Polymorphs are well known to have different mechanical properties. Nanoindentation enables mechanical properties to be tested on single crystals, which should provide the best opportunity to establish a correlation with single-crystal X-...

Lactose, one of the most commonly used fillers in solid dosage formulations, is well known for producing tablets with high mechanical strength. However, its usage has been eroded by some relatively recent concerns, such as Bovine Spongiform Encephalopathy BSE, Variant Creutzfeldt-Jacob Disease (vCJD), and lactose intolerance. These concerns have led some formulators to evaluate other excipients...

The topic of this article is the compression physics of different gum bases which can be used to prepare chewing gumtablets by direct compression. Three different gum bases, Pharmagum® C, M and S, were tested alone and in differentcombinations. The preparations were compressed with a Korsch EK0 eccentric tableting machine at compressionforces of 5, 7.5, 10, 12.5 and 15 kN. The c...

Characterization of the entire densification process is really difficult by using one simple monovariate equation to be successfully applied in research and development of tablet formulation. Particle rearrangement process can be divided into two steps and described by biexponential Heckel equation. By non-linear approach quantification of compactibility, compressibility and tabletability of th...

The paper studies the compressibility of directly compressible tableting materials with dry binders, spray-dried lactose and microcrystalline cellulose, and glyceryl dibehe nate at various concentrations. Compressibility was evaluated by means of the energy profile of compression and tensile strength of tablets. Release rate of the active ingredient, salicylic acid, from the tablets was also ex...