www.pharmtech.com new chemical entity often is first formulated as a free-flowing granulation for encapsulation within hard gelatin capsules. During the course of clinical development, the drugcontaining granulation usually is modified for compaction into a tablet product. The tablet product subsequently may be film coated for taste masking, identification, or other purposes. Tablets are the mo...

The purpose of this study was to obtain a nicorandil pulsatile release tablet that has a well-regulated release lag time. When nicorandil is used as an antiangina drug, administration time control is important. A pulsatile release tablet is one of the effective approaches to modified release to reduce daily administration frequency. In this study, a pulsatile release tablet of nicorandil was fo...

Computers are now widely used by children. Tablet computers are becoming widely available and promoted for use by school children. The primary objective of this study was to compare the posture and muscle activity of children using a tablet computer to the posture and muscle activity of children using a desktop computer and paper technology. Eighteen children (mean age 5.6 years) performed a co...

Rationale: Table compression process has a profound effect on different quality attributes of table manufacturing process such as appearance, content uniformity, hardness, thickness, friability, Disintegration time and Dissolution time. Among all the table compression parameters, feeder speed, precompression, main compression forces and Turret speed have a substantial effect on tablet propertie...

Sediaan Orally Disintegrating Tablet (ODT) merupakan sistem penghantaran obat dengan disintegrasi yang cepat dalam waktu kurang dari 60 detik. ODT umumnya menggunakan bahan penghancur dapat mempercepat hancurnya tablet rongga mulut tanpa melalui proses pembentukan gel, antara lain crospovidone. Penelitian ini bertujuan mengetahui pengaruh penambahan crospovidone pembuatan loratadin metode granu...

The objective of the study is to formulate mouth dissolving Tablet Moexipril with a variety super disintegrants and compare marketed disintegration tablet

Dear Editor,  I read with great interest the brief report entitled "Aluminum Phosphide Poisoning: A Case Series in North Iran" presented by Nosrati et al. and published recently in your journal (1). I have a question from authors and also a suggestion regarding aluminum phosphide (AlP) poisoning- related studies. I would like to ask authors how they validate the study results, since it is not...

the aim of the present study was to prepare an oral tablet from liquid yogurt by reforming the physical properties for easy transportation, long-term storage and also as a complementary dairy product in case of nutrient deficiency. the liquid fresh yogurt was lyophilized at -40°c and 0.03 mtor pressure. the dry powder was homogenized by a 12 mesh size sieve. some tests such as carr’s compressib...

a sustained-release tablet formulation should ideally have a proper release profile insensitive to moderate changes in tablet hardness that is usually encountered in manufacturing. in this study, matrix aspirin (acetylsalicylic acid) tablets with ethylcellulose (ec), eudragit rs100 (rs), and eudragit s100 (s) were prepared by direct compression. the release behaviors were then studied in two co...

in the present investigation an attempt has been made to increase therapeutic efficacy, to reduce frequency of administration and to improve patient compliance by developing a sustained release matrix tablets of isosorbide-5-mononitrate. sustained release matrix tablets of isosorbide-5-mononitrate were developed by using different drug: polymer ratios, such in f1 (1:0.75), f2 (1:1), f3 (1:1.5),...