نتایج جستجو برای: tab2 composite
تعداد نتایج: 121748 فیلتر نتایج به سال:
The role of receptor tyrosine kinases (RTKs) in transmembrane signaling is well established. Recently, ligand-dependent translocation of RTKs to the nucleus has been reported, but the functional importance of this process remains unclear. In this issue, Sardi et al. (2006) provide evidence for direct signaling in the nucleus by an intracellular ErbB4 receptor fragment that is released upon rece...
Rank # Genes Highest OR (L95-U95) Smallest P-value # Genes Highest OR (L95-U95) Smallest P-value # Genes Highest OR (L95-U95) Smallest P-value 1 IRAK1 0.70 (0.55-0.90) 0.006 IRAK1 0.73 (0.54-0.99) 0.042 IRAK1 0.50 (0.28-0.86) 0.013 2 MKK3 1.28 (1.10-1.50) 0.002 IRAKM 0.53 (0.31-0.90) 0.019 SIGIRR 0.54 (0.35-0.85) 0.008 3 ERK2 1.22 (1.05-1.42) 0.010 RIP1 1.49 (1.04-2.12) 0.012 TRAF6 0.65 (0.46-0...
PURPOSE MicroRNAs (miRNAs) have emerged as a class of gene expression regulators involved in immune regulation. In the present study, we investigated the role of miRNA in two uveitis entities: Behcet's disease (BD) and Vogt Koyanagi Harada syndrome (VKH). METHODS The expression of five miRNAs was studied in PBMCs, DCs, and CD4(+) T cells from BD patients with active and inactive uveitis, VKH ...
Transforming growth factor-beta-activated kinase 1 (TAK1), an MAP3K, is a key player in processing a multitude of inflammatory stimuli. TAK1 autoactivation involves the interplay with TAK1-binding proteins (TAB), e.g. TAB1 and TAB2, and phosphorylation of several activation segment residues. However, the TAK1 autoactivation is not yet fully understood on the molecular level due to the static na...
Brucella spp. infection results in compromised Type1 (Th1) cellular immune response. Several reports have described an immunomodulatory function for Brucella major outer membrane protein Omp25. However, the mechanism by which Omp25 modulates macrophage dysfunction has not been defined. Herein, we reported that Omp25-deficient mutant of Brucella suis exhibited an enhanced ability to induce inter...
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