introduction: extranodal natural killer (nk)/t-cell lymphoma (nktcl) nasal type is a rare but well-known disease with poor prognosis. nktcl is more prevalent in asia and comprises about 7-10% of all non-hodgkin lymphoma cases in this region. the characteristic clinical pattern of nktcl is the destruction of the midline structures of the mid-face. case report: the present study examines a case o...

aerial parts of salvia mirzayanii was extracted with methanol. methanol extract was suspended in water and defatted with petroleum ether. the defatted part was then partitioned between ethyl acetate and water. the ethyl acetate partition was chromatographed on a silica gel column to afford several fractions. lymphocyte proliferation inhibitory assay of the resulted fractions was compared in vit...

mesenchymal stem cells can be obtained from deferent tissues like adipose tissue, umbilical cord, placenta, skin, bone marrow, etc. these cells have regulatory effects on all types of immune cells such as dendritic cell, natural killers and lymphocytes. mesenchymal stem cells induce inhibitory phenotypes of antigen presenting cells (apcs) following their activity. they also change t cells pheno...

conclusions fmf should be considered in patients who present with alopecia, acne like lesions, cysts and comedones in older ages with a spectrum of histologic changes. we emphasize for any time it should be under-recognized. introduction folliculotropic mycosis fungoides (fmf) is a variant of mycosis fungoides characterized by the presence of folliculotropic atypical tcells infiltrates, often w...

background: mesenchymal stem cells (msc) have ability to regulate immune response via proinflamatory cytokines. in this study we aimed to investigate the effect of different mechanism for t cell activation and adjacency on immunoregulatory properties of msc. methods: bone marrow mscs were purchased and t cells were obtained from whole blood sample. t cells were activated by two different mechan...

non-hodgkin lymphoma is very uncommon in infancy and skin as the primary site of involvement in non-hodgkin lymphoma is rarely encountered. we describe a 10-month-old infant with t-cell non-hodgkin lymphoma who presented with multiple skin nodules as the predominant feature of her disease. the clinical manifestations, treatment strategy and disease outcome are reviewed. key words: non-hodgkin l...

mitochondrial functions have a major impact on t-cell functionality. in this study we characterized whether mitochondrial function in the neonatal t-cells differs from that in the adult t-cells during short t-cell activation. methods: we used fow cytometry methods to test mitochondrial mass and to monitor mitochondrial ca2+ levels, mitochondrial potential and superoxide generation in parallel w...