background: memory impairment is a well-known effect of many benzodiazepine compounds which is mediated through their action on gamma-aminobutyric acid type a (gabaa) receptors. on the other hand, cannabinoids can affect learning and memory process through presynaptic modulation of the release of both excitatory glutamate and inhibitory gaba transmitters in brain regions involved in learning an...

in this study, aluminosilicate mcm-41 has been found to be an efficient catalyst for reaction betweendifferent benzaldehyde derivatives and 5,5-dimethyl-1,3-cyclohexanedione to give open chain analogue of1,8-dioxo-octahydroxanthene in excellent yields. no evidence for the formation of cyclization products wasobserved. the catalyst can be used several times after recovery.

the genus tanacetum is one of the most important medicinal plants that contains 26 species in iran, 12 of them are endemic. this paper reports the essential oil composition of  tanacetum angulatum willd. tanacetum canacens dc. and tanacetum pinnatum boiss. growing wild in iran. plant flowers and leaves were collected from different locations of north- west of iran. samples were hydro-distilled ...

sulfonamides are the first effective chemotherapeutic agents used for several years to cure or prevent systemic bacterial infections. in addition, this agents showed anti-carbonic anhydrase and cause cell cycle perturbation in the g1 phase, disruption of microtubule assembly, suppression of the transcription activator nf-y, angiogenesis and matrix metalloproteinase (mmp). in recent years, novel...

existence of 2-methylpropane-2-thiol as an organosulfur and odorant compound in the soil could causes environmental problem and social dissatisfaction. in this study, remediation of this type of thiol using ultrasound is investigated. central composite design (ccd) based on response surface model (rsm) was used to obtain effects of the main factor (power, sonication time and amount of water) an...

experimental  autoimmune  encephalomyelitis (eae)  is  a  mouse  model  for  multiple sclerosis (ms), this autoimmune disease is mainly mediated by adaptive and innate immune responses that lead to an inflammatory demyelination and axonal damage. imatinib mesylate is a  selective protein  tyrosine kinase inhibitor  with immunomodulatory  properties  that abrogates multiple signal transduction p...