Severe acute pancreatitis (SAP) starts as a local inflammation of pancreatic tissue that induces the development of multiple extrapancreatic organs dysfunction; however, the underlying mechanisms are still not clear. Ischemia-reperfusion, circulating inflammatory cytokines, and possible bile cytokines significantly contribute to gut mucosal injury and intestinal bacterial translocation (BT) dur...

Sleep Apnea Syndrome (SAS) is a sleep related-breathing disorder with several features such as systemic inflammation, oxidative stress, cognitive impairment and poor quality. Patients SAS have an increased risk of cardiovascular diseases. There no real effective treatment that prevents treats all these illness symptoms. Cooling therapies are often used in sport medicine athletes after training ...

hemophagocytic syndrome (hps) is an uncommon manifestation in systemic lupus erythematosus (sle). clinical features of hps include fever, pancytopenia, abnormal liver enzyme, hepatosplenomegaly, lymphadenopathy, and coagulation disorder. hps comprises primary and reactive forms. herein, we describe a case of untreated sle with hps as one of the first manifestations of systemic lupus.

Inflammation is widely known to play a key role in the development and progression of cardiovascular diseases. It is becoming increasingly evident that obesity is linked to many proinflammatory and obesity-associated cardiovascular conditions (e.g., metabolic syndrome, acute coronary syndrome, and congestive heart failure). It has been observed that adipokines play an increasingly large role in...

Introduction Sepsis is a syndrome of systemic inflammation arising from infection that constitutes a top-ten cause of adult mortality. The recent withdrawal of a specific sepsis therapeutic has diminished pharmaceutical enthusiasm for developing novel drugs in this domain. Angiopoietin-2 (Angpt-2) is an endothelial-derived protein that potentiates vascular inflammation and permeability and may ...

Abstract The multisystem inflammatory syndrome in children (MIS-C) is a post-viral immunological or hyper-inflammatory complication of severe acute respiratory coronavirus-2 (SARS-CoV-2) infection commonly seen older children, who present with fever, multi-systemic involvement including myocardial dysfunction and shock, hyper-inflammation. treatment MIS-C adapted from the other conditions these...

procalcitonin (pct) is a precursor peptide for the hormone calcitonin and is frequently increased in overt sepsis. the aim of this study was to test diagnostic accuracy of procalcitonin among patients with positive systemic inflammatory response syndrome (sirs) in identifying sepsis. in this cross sectional study, from 563 patients with positive sirs admitted through the emergency department of...

The parotid gland may enlarge during the course of systemic lupus erythematosus (SLE). Shearn and Pirofsky (1952) were the first to draw attention to this association while studying a group of 34 patients who had systemic lupus erythematosus. They discovered sialoadenitis characterized by chronic, nonsuppurative inflammation unilaterally in one and bilaterally in two patients. Morgan (1954) rep...

The early, delayed, and systemic effects of acute traumatic brain injury (TBI) are the result of inflammatory mediators which initiate systemic inflammatory response syndrome (SIRS), subsequent complement deficits and coagulopathy. Once SIRS is triggered by acute inflammation, it can detrimentally self-propagate. Systemic inflammation causes tissue damage leading to further inflammation and dam...