Dyslipidemia has been widely proven to contribute to cardiovascular diseases and other metabolic disorders, especially in insulin resistance and type 2 diabetes. The overproduction of VLDL is a significant characteristic of dyslipidemia, indicating the dysfunction of hepatic lipid metabolism, from triglyceride synthesis to transport. The fructose-fed Syrian golden hamster is an established anim...

Male reproductive behavior in the Syrian hamster is dependent on both pheromones from the female and the presence of gonadal steroid hormones. The pheromones are contained within female hamster vaginal secretions (FHVS) and stimulate anogenital investigation and mounting by the male. Administration of testosterone to castrated male hamsters facilitates anogenital investigation, mounts, and intr...

The p16(INK4A)/CDKN2A tumor suppressor gene is known to be inactivated in up to 98% of human pancreatic cancer specimens and represents a potential target for novel therapeutic intervention. Chemically induced pancreatic tumors in Syrian golden hamsters have been demonstrated to share many morphologic and biological similarities with human pancreatic tumors and this model may be appropriate for...

The progression of normal Syrian hamster embryo cells to a neoplastic phenotype after treatment with a chemical carcinogen and continuous exposure to phorbol ester tumor promoters was studied in cell culture. Tumor promoters were able to rescue cell lines derived from individual carcinogen-treated colonies from a program of cellular senescence. In general, these cell lines did not grow in soft-...

We have developed a qualitative and quantitative assay system for detecting cells lacking postconfluence inhibition of cell division (contact insensitivity, CS~) in golden Syrian ham ster embryo cells in culture by measuring the number of cells able to form colonies on a lethally irradiated, confluent monolayer of a contact-sensitive established cell line. A subpopulation in normal low-passage ...

We have previously found that cyclooxygenase-2 (COX-2), a key enzyme in the biosynthesis of prostaglandins (PGs), is present in the testicular interstitial cells of infertile men, whereas it is absent in human testes with no evident morphological changes or abnormalities. To find an animal model for further investigating COX-2 and its role in testicular steroidogenesis, we screened testes from ...

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic amine carcinogen present in well-done meat. PhIP must undergo host-mediated bioactivation to exert its mutagenic and carcinogenic effects. Following N-hydroxylation, N-acetyltransferases catalyze the O-acetylation (activation) of N-hydroxy-PhIP to an electrophile causing DNA damage. A well-defined genetic polymorphism in N...

Abstract The COVID-19 pandemic progresses unabated in many regions of the world. An effective antiviral against SARS-CoV-2 that could be administered orally for use following high-risk exposure would substantial benefit controlling pandemic. Herein, we show MK-4482, an nucleoside analog, inhibits replication Syrian hamster model. inhibitory effect MK-4482 on is observed animals when drug either...