OBJECTIVES The aims were to isolate and positively identify the microfibrillar elements which have been observed in the synovial lining. In addition, synovial fluid was examined for these elements to improve the understanding of the role of these structures in health and disease. METHODS Bacterial collagenase digestion of bovine synovial linings and human and bovine synovial fluids was used t...

A high performance liquid chromatography (HPLC) procedure suitable for the simultaneous determination of the molecular size and concentration of macromolecular hyaluronate and proteoglycans in synovial fluid has been developed. Irrigation of the equine tarsocrural joint with 20 ml physiological saline (PSS) caused a mild inflammation with an increase of proteoglycans in the synovial fluid over ...

Synovial fluid is generally considered to be a dialysate of plasma to which mucin has been added during its passage through the synovial membrane (Ropes and Bauer, 1953). The proteins of the serum and synovial fluid have been shown to be qualitatively identical (Schmid and MacNair, 1956) and the concentrations of the various proteins in synovial fluid probably depend upon the following factors:...

background accurate and rapid diagnosis of bacterial arthritis is not always possible in unvaccinated (streptococcus pneumoniae and haemophilus influenzae type b) children in iran. objectives searching the staphylococcal superantigen (entrotoxin a, b, c and tsst1) in synovial fluid of cases with inflammatory arthritis. patients and methods this cross sectional study was implemented in the pedia...

High levels of rheumatoid factors (RF) are detectable in serum of the majority of patients with rheumatoid arthritis (RA), but 5-10% of patients remain seronegative (SN). Despite clinical and genetic similarities between these two subsets of RA, it has been proposed that they may be regarded as distinct clinical entities. Methods: In the present study a panel of monoclonal antibodies (mAb) rec...

BACKGROUND Connective tissue growth factor (CTGF) has been implicated in development of osteoarthritis (OA). OBJECTIVE To determine the correlation between plasma and synovial fluid CTGF levels and the severity in knee osteoarthritis patients. METHODS A total of 100 subjects were recruited into this study (75 OA patients and 25 controls). CTGF concentrations in plasma and synovial fluid wer...

Synovial fluid is a viscous solution found in the cavities of synovial joints. The principal role of synovial fluid is to reduce friction between the articular cartilages of synovial joints during movement. The presence of high molar mass hyaluronan (HA) in this fluid gives it the required viscosity for its function as lubricant solution. Inflammation oxidation stress enhances normal degradatio...