This study demonstrates the use of a selective and sensitive voltammetric sensor for determination of acetaminophen (AC). This was  performed by modifying a glassy carbon electrode with composite film of poly(4-vinylpyridine) and graphene sheet (P4VP/GR-GCE). The redox peak currents of AC increased significantly at P4VP/GR-GCE. The result was achieved by the synergistic effect of combined elect...

In vitro and in vivo studies are presented to test the hypothesis that the synergistic action of the pristinamycins is not due to a catalytic effect of pristinamycin IIA (PIIA) on the bacterial ribosome. We demonstrate that there is a proportionality between the quantity of PIIA bound on the ribosome and pristinamycin IA (PIA) retained by it. Moreover in vitro and in vivo experiments correlated...

We investigated the performance of nickel/samarium-doped ceria (Ni/SDC) nanocatalysts on catalytic partial oxidation methane (CPOM). Studies temperature-programmed surface reaction and reduction reveal that activity is determined by a synergistic effect produced Ni metals metal-support interaction. Catalytic was more dependent content below 600 °C, while there not much difference for all cataly...

Farnesyl transferase (FT) inhibitors (FTI) are anticancer agents developed to target oncogenic Ras proteins by inhibiting Ras farnesylation. FTIs potently synergize with paclitaxel and other microtubule-stabilizing drugs; however, the mechanistic basis underlying this synergistic interaction remains elusive. Here we show that the FTI lonafarnib affects the microtubule cytoskeleton resulting in ...

A novel Ag2O/TiO2-modified chitosan-based photocatalytic film with high adsorption and photocatalytic activity was synthesized under simulated solar irradiation, based upon the coupling of the synergistic catalytic technique of nano Ag2O/TiO2 and membrane separation. XRD, XPS, FESEM, and TEM characterization results illustrated that the Ag2O nanoparticles with a small size of 3–5 nm deposited o...

Compared with monometallic selenides, heterogeneous bimetallic selenides have rich phase boundaries and superior electrical conductivity. ZnSe/CoSe2 composites were prepared by introducing Zn metal using ZIF-8/67 as the precursor through synergistic effect between Co after selenification. The electrocatalytic conversion of polysulfide is accelerated ZnSe chemical adsorption catalytic effect. co...

We recently showed that poly(ADP-ribose) polymerase (PARP) inhibitors exert their cytotoxicity primarily by trapping PARP-DNA complexes in addition to their NAD(+)-competitive catalytic inhibitory mechanism. PARP trapping is drug-specific, with olaparib exhibiting a greater ability than veliparib, whereas both compounds are potent catalytic PARP inhibitors. Here, we evaluated the combination of...

Synergistic catalysis is a synthetic strategy wherein both the nucleophile and the electrophile are simultaneously activated by two separate and distinct catalysts to afford a single chemical transformation. This powerful catalysis strategy leads to several benefits, specifically synergistic catalysis can (i) introduce new, previously unattainable chemical transformations, (ii) improve the effi...