Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation. Am J Obstet Gynecol 2002;186:158–66. 12. Redman CWG, Sacks GP, Sargent IL. Preeclampsia, an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 1999;180:499– 506. 13. Smarason AK, Sargent IL, Starkey PM, Redman CWG. The effect of pl...

Nitric oxide (NO) regulates blood flow in the human placenta. As increased resistance to blood flow is seen in the fetal-placental vasculature in pregnancies complicated by pre-eclampsia and/or intrauterine growth restriction (IUGR), we examined expression of endothelial nitric oxide synthase (eNOS) in these placentas. Placental villous tissue sections were obtained from normotensive control (n...

Organic anion-transporting polypeptides (OATPs) are a family of multispecific carriers that mediate the sodium-independent transport of steroid hormone and conjugates, drugs, and numerous anionic endogenous substrates. We investigated whether members of the OATP gene family could mediate fetal-maternal transfer of anionic steroid conjugates in the human placenta. OATP-B (gene symbol SLC21A9) wa...

Previous studies have reported the presence of high-affinity angiotensin II (Ang II) binding sites in human placental tissue, but it has not been determined whether these are located in brush border (BBM) or basolateral plasma (BPM) membranes of the syncytiotrophoblast. Our findings provide no evidence for Ang II receptors in BBM, yet they reveal a single class of binding sites in BPM preparati...

The investigation of human placental nutrient transfer and hormonal secretion presents a particular challenge because these processes depend on the intactness and orientation of the unicellular epithelial sheet of villous syncytiotrophoblast that mediates them. The isolated perfused placental cotyledon retains the architecture of the villi and has been very useful, but the presence of the non-t...

The study of placental lactogen by immunohistochemistry in histological sections the placenta during physiological pregnancy and on background iron deficiency anemia aspect chronic insufficiency. It is established that gestation against decreases production syncytiotrophoblast chorionic villi correlates with state blood pregnant woman. optical density immunohistochemical staining for free troph...

We tested two hypotheses: 1) that fibrin-containing fibrinoid-filled denudations of the syncytiotrophoblast may provide a route for paracellular diffusion and 2) that placentas from women who had elevated maternal serum alphafetoprotein (MSAFP) in midgestation had raised permeability to AFP and greater denudation than in normal pregnancy. We measured AFP and creatinine clearance across term pla...