نتایج جستجو برای: sustained virologic response

تعداد نتایج: 1043902  

2017
Jim Young Nina Weis Harald Hofer William Irving Ola Weiland Emiliano Giostra Juan Manuel Pascasio Lluis Castells Martin Prieto Roelien Postema Cinira Lefevre David Evans Heiner C. Bucher Jose Luis Calleja

BACKGROUND There is limited evidence for the effectiveness of daclatasvir in patients whose hepatitis C threatens their life expectancy. The Named Patient Program in Europe included patients with advanced chronic hepatitis C, a life expectancy of less than 12 months and no other treatment options. METHODS A retrospective multi-country cohort of patients with chronic hepatitis C who received d...

2015
Xavier Forns Fred Poordad Marcos Pedrosa Marina Berenguer Heiner Wedemeyer Peter Ferenci Mitchell L. Shiffman Michael W. Fried Sandra Lovell Roger Trinh Juan Carlos Lopez‐Talavera Gregory Everson

BACKGROUND & AIMS Thrombocytopaenia and hypoalbuminaemia are surrogate markers for portal hypertension and hepatic synthetic dysfunction respectively. Patients infected with hepatitis C virus (HCV) with these surrogates have reduced likelihood of sustained virologic response and increased risk for hepatic decompensation or death when treated with peginterferon/ribavirin plus either telaprevir o...

2012
Curtis L Cooper Eric Druyts Kristian Thorlund Jean B Nachega Antoine C El Khoury Christopher O’Regan Edward J Mills

BACKGROUND The aim of this study was to examine the relative efficacy and safety of boceprevir and telaprevir, when used in combination with pegylated interferon alpha and ribavirin, using an indirect comparison meta-analysis. METHODS Published phase II and phase III randomized placebo-controlled trials examining the efficacy of boceprevir and telaprevir in chronic hepatitis C virus genotype ...

Journal: :The New England journal of medicine 2015
Graham R Foster Nezam Afdhal Stuart K Roberts Norbert Bräu Edward J Gane Stephen Pianko Eric Lawitz Alex Thompson Mitchell L Shiffman Curtis Cooper William J Towner Brian Conway Peter Ruane Marc Bourlière Tarik Asselah Thomas Berg Stefan Zeuzem William Rosenberg Kosh Agarwal Catherine A M Stedman Hongmei Mo Hadas Dvory-Sobol Lingling Han Jing Wang John McNally Anu Osinusi Diana M Brainard John G McHutchison Francesco Mazzotta Tram T Tran Stuart C Gordon Keyur Patel Nancy Reau Alessandra Mangia Mark Sulkowski

BACKGROUND In phase 2 trials, treatment with the combination of the nucleotide polymerase inhibitor sofosbuvir and the NS5A inhibitor velpatasvir resulted in high rates of sustained virologic response in patients chronically infected with hepatitis C virus (HCV) genotype 2 or 3. METHODS We conducted two randomized, phase 3, open-label studies involving patients who had received previous treat...

Journal: :The New England journal of medicine 2014
Fred Poordad Christophe Hezode Roger Trinh Kris V Kowdley Stefan Zeuzem Kosh Agarwal Mitchell L Shiffman Heiner Wedemeyer Thomas Berg Eric M Yoshida Xavier Forns Sandra S Lovell Barbara Da Silva-Tillmann Christine A Collins Andrew L Campbell Thomas Podsadecki Barry Bernstein

BACKGROUND Interferon-containing regimens for the treatment of hepatitis C virus (HCV) infection are associated with increased toxic effects in patients who also have cirrhosis. We evaluated the interferon-free combination of the protease inhibitor ABT-450 with ritonavir (ABT-450/r), the NS5A inhibitor ombitasvir (ABT-267), the nonnucleoside polymerase inhibitor dasabuvir (ABT-333), and ribavir...

Journal: :Blood 2005
David Saadoun Felipe Suarez François Lefrere Françoise Valensi Xavier Mariette Achille Aouba Caroline Besson Bruno Varet Xavier Troussard Patrice Cacoub Oliver Hermine

Hepatitis C virus (HCV) has been associated with the development of B-cell non-Hodgkin lymphomas. We recently reported the regression of splenic lymphoma with villous lymphocytes (SLVL) in patients with HCV after antiviral treatment, demonstrating a direct role of HCV in lymphomagenesis. This study expands our previous results in 18 patients with chronic HCV and SLVL. Mixed cryoglobulinemia (MC...

Journal: :The New England journal of medicine 2017
Edward Gane Eric Lawitz David Pugatch Georgios Papatheodoridis Norbert Bräu Ashley Brown Stanislas Pol Vincent Leroy Marcello Persico Christophe Moreno Massimo Colombo Eric M Yoshida David R Nelson Christine Collins Yang Lei Matthew Kosloski Federico J Mensa

BACKGROUND Chronic hepatitis C virus (HCV) infection is more prevalent among patients who have chronic kidney disease than among those who do not have the disease. Patients with chronic kidney disease who also have HCV infection are at higher risk for progression to end-stage renal disease than those who have chronic kidney disease without HCV infection. Patients with both HCV infection and adv...

Journal: :The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2006
Necati Yenice Ozgür Mehtap Mübeccel Gümrah Nurten Arican

BACKGROUND/AIMS We aimed to compare viral responses to pegylated interferon 2a plus ribavirin with pegylated interferon alpha 2b plus ribavirin. METHODS Patients with the following characteristics were included: anti HCV(+); normal and/or elevated serum transaminase levels; positive HCV RNA by quantitative PCR; and at least stage 1 fibrosis according to Knodell Scoring System on liver biopsy....

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