Naturally ligand independent constitutively active gp130 variants were described to be responsible for inflammatory hepatocellular adenomas. Recently, we genetically engineered a ligand-independent constitutively active gp130 variant based on homodimerization of Jun leucine zippers. Because also heterodimeric complexes within the gp130 family may have tumorigenic potential, we seek to generate ...

We propose a framework for inferring the latent attitudes or preferences of users by performing probabilistic first-order logical reasoning over the social network graph. Our method answers questions about Twitter users like Does this user like sushi? or Is this user a New York Knicks fan? by building a probabilistic model that reasons over user attributes (the user’s location or gender) and th...

We introduce TopPI, a new semantics and algorithm designed to mine long-tailed datasets. For each item, and regardless of its frequency, TopPI finds the k most frequent closed itemsets that item belongs to. For example, in our retail dataset, TopPI finds the itemset “nori seaweed, wasabi, sushi rice, soy sauce” that occurrs in only 133 store receipts out of 290 million. It also finds the itemse...

We propose a method of using clustering techniques to partition a set of orders. We define the term order as a sequence of objects that are sorted according to some property, such as size, preference, or price. These orders are useful for, say, carrying out a sensory survey. We propose a method called the ko’means method, which is a modified version of a k-means method, adjusted to handle order...