A 66-year-old man with hypertension presented with right-sided numbness and slurred speech. MRI revealed a large left frontoparietal area of T2-weighted hyperintensity with focus of central enhancement (figure, A and B). The patient’s symptoms self-resolved within weeks. Over the next 2 years, he experienced multiple relapses including encephalopathy characterized by headache with motor aphasia...

Introduction Susac Syndrome (SS) is an immune-mediated endotheliopathy that mainly affects young women. It characterized by the typical triad: subacute encephalopathy, retinal vaso-occlusive disease, and hearing loss. Encephalopathy symptoms are varied include memory loss, psychiatric disturbances, cranial nerve disorders, seizures, dementia. The syndrome considered a rare but important differe...