OBJECTIVES Details of abnormal prion protein (PrP(Sc)) propagation in the human central nervous system (CNS) are unclear. To assess the spread of PrP(Sc) through the human CNS, we evaluated dura mater graft-associated Creutzfeldt-Jakob disease (dCJD) cases focusing on sites of grafting and dCJD pathological subtypes. DESIGN A cross-sectional study. SETTING nationwide surveillance data of hu...

Crossed cerebellar diaschisis (CCD) describes a depression of oxidative metabolism glucose and blood flow in the cerebellum secondary to a supratentorial lesion in the contralateral cerebral hemisphere. PET/MR has the potential to become a powerful tool for demonstrating and imaging intracranial lesions .We herein report 3 cases of CCD imaging using a tri-modality PET/CT–MR setup for investigat...

OBJECTIVE Remote cerebellar hemorrhage (RCH) is one of the rare complications occurring after supratentorial surgery, and its pathomechanism is poorly understood. We report 10 cases of RCH from our institution and review 154 cases from a database in order to delineate incidence, common presentation, risk factors, and outcomes of this complication. In addition, the means of prevention are discus...

Acute isolated hemiataxia is in most cases due to infratentorial (cerebellar) stroke. It has only twice been described in supratentorial stroke--namely, after thalamic infarction and a capsular haemorrhage. Three patients with isolated hemiataxia after a supratentorial brain infarct are described. These patients were seen in a period of five years during which 899 patients with a first supraten...

A 33-year-old male presented with a headache. He had a history of a previous surgical procedure for excisions of cervical spine hemangioblastomas 13 years prior He had a family history of von-Hippel Lindau (VHL) disease, and a VHL mutation was identified. Brain magnetic resonance imaging showed enhanced mass lesions in both the third and right lateral ventricles as well as in the cerebellum. Th...

BACKGROUND Neurenteric cysts are congenital cysts of the central nervous system that are believed to be of endodermal origin. In this report we present the unique case of a supratentorial neurenteric cyst that is contained entirely within the brain parenchyma. METHODS A patient presented with an intraparenchymal cystic lesion that was subsequently identified as a neurenteric cyst. This lesion...

BACKGROUND Ependymomas usually arise from the ventricular surface. METHODS We report an 11-year-old female who presented with a supratentorial ectopic ependymoma. RESULTS The patient presented with a two-month-history of progressive headache, nausea and vomiting. Examination revealed papilledema, horizontal nystagmus, diplopia on upward gaze, and right pronator drift. CT scan showed an enha...

Background and Purpose: Malignant, non-enhancing supratentorial gliomas (G) and neuronal-glial (NG) tumors are sometimes misdiagnosed as low grade tumors. Earlier studies have indicated that up to 45% of the non-enhancing supratentorial gliomas are malignant. Diffusion tensor imaging (DTI) can supply multiple diffusion indices of which minimal apparent diffusion coefficient (ADC) and ratio Frac...