Objective: The aim of this study was to evaluate the effect of zinc and magnesium supplementation on glycemic control and serum insulin in type 2 diabetic patients. Materials and Methods: In this randomized clinical trial 70 diabetic patients who referred to Yazd Diabetes Center were selected. Subjects received 500 mg/day magnesium oxide or 100 mg/day zinc sulfate randomly for 8 weeks. At th...

BACKGROUND The efficacy of preventive zinc supplementation against diarrhea and respiratory illness may depend on simultaneous supplementation with other micronutrients. We aimed to assess the effect of supplementation with zinc and multiple micronutrients on diarrhea and other causes of non-malarial morbidity. METHODS AND FINDINGS Rural Tanzanian children (n = 612) aged 6-60 months and with ...

BACKGROUND The effect of different ways of zinc supplementation on spatial learning and memory remains unclear. OBJECTIVES This study aims to assess the effectiveness of two ways of zinc supplementation - oral use and intravenous transfusion - in zinc-deficient offspring rats on learning and memory. DESIGN Rats were randomly divided into six groups on the first day of pregnancy (n=12): cont...

BACKGROUND Zinc deficiency is commonly prevalent in children in developing countries and plays a role in decreased immunity and increased risk of infection. Preventive zinc supplementation in healthy children can reduce mortality due to common causes like diarrhea, pneumonia and malaria. The main objective was to determine all-cause mortality and cause-specific mortality and morbidity in childr...

BACKGROUND Adjustments in zinc losses and absorption are thought to maintain zinc homeostasis with changes in intake, but the capacity to make these adjustments appears to be affected by aging. Zinc status of the individual may also influence adjustments in fractional zinc absorption. OBJECTIVE The purpose of this study was to compare the effects of changes in zinc status due to zinc suppleme...

hyperglycemia and gestational diabetes mellitus are complications of pregnancy. both mothers and newborns are typically at increased risk for complications. this study sought to determine effect of zinc supplementation on serum glucose levels, insulin resistance, energy and macronutrients intakes in pregnant women with impaired glucose tolerance.in this clinical trial 44 pregnant women with imp...

Maternal zinc deficiency during pregnancy has been related to adverse effects on progeny, and there are data showing that mild to moderate zinc deficiency (as assessed by available indicators) is quite common in the developing world. Observational data relating zinc deficiency to adverse fetal outcome have produced conflicting results, mainly because of the lack of a valid indicator of zinc def...

QUESTION Gastroenteritis with diarrhea is a common condition in children, potentially leading to dehydration, morbidity, and in some countries substantial mortality. Is there a role for zinc supplementation in these cases? ANSWER Zinc can be found in a variety of foods, and in Canada some foods are fortified with zinc. Zinc supplementation was shown to be a safe and effective measure to short...

Assessment of zinc status remains a challenge largely because serum/plasma zinc may not accurately reflect an individual's zinc status. The comet assay, a sensitive method capable of detecting intracellular DNA strand breaks, may serve as a functional biomarker of zinc status. We hypothesized that effects of zinc supplementation on intracellular DNA damage could be assessed from samples collect...