Candida rugosa lipase immobilized on maghemite nanoparticles demonstrated high stereoselectivity in kinetic resolution of racemic carboxylates and improved long-term stability over its parent free enzyme, allowing the supported enzyme to be repeatedly used for a series of chiral resolution reactions.

BBB blood-brain barrier BMEC brain microvascular (capillary) endothelial cells CBSA cationic bovine serum albumin CdTe cadmium tellurium CTAB trimethylammonium bromide DRG dorsal root ganglia HSA human serum albumin ip intraperitoneal iv intravenous MWCNT multi-walled carbon nanotube PAMAM poly(amidoamine) PBCA polybutylcyanoacrylate PEG polyethylene glycol PLA poly(lactide) PLGA poly(lactic-co...

UNLABELLED In this work, the magnetic properties of silicon nanotubes (SiNTs) filled with Fe3O4 nanoparticles (NPs) are investigated. SiNTs with different wall thicknesses of 10 and 70 nm and an inner diameter of approximately 50 nm are prepared and filled with superparamagnetic iron oxide nanoparticles of 4 and 10 nm in diameter. The infiltration process of the NPs into the tubes and dependenc...

results the maximum si was obtained at the highest applied flip angle (45°). the linear relationship between si and nanoparticle concentration was seen up to 112.21 and 98.83 μmol fe/l for the short (10°) and the long (45°) flip angles, respectively (r2 = 0.95). these values were reduced up to 48.54 and 42.73 μmol fe/l for these flip angles with r2 of 0.99. conclusions the maximum si will be in...

Vascular occlusion can result in fatal myocardial infarction, stroke or loss of limb in peripheral arterial disease. Interventional balloon angioplasty is a common first line procedure for vascular disease treatment, but long term success is limited by restenosis and neointimal hyperplasia. Cellular therapies have been proposed to mitigate these issues; however efficacy is low, in part due to p...

BACKGROUND The role of local alterations in endothelial functional integrity in atherosclerosis remains incompletely understood. This study used nanoparticle-enhanced optical molecular imaging to probe in vivo mechanisms involving impaired endothelial barrier function in experimental atherothrombosis. METHODS AND RESULTS Atherosclerosis was induced in rabbits (n=31) using aortic balloon injur...

Superparamagnetic iron oxide nanoparticles are widely used in biomedical applications, yet questions remain regarding the effect of nanoparticle size and coating on nanoparticle cytotoxicity. In this study, porcine aortic endothelial cells were exposed to 5 and 30 nm diameter iron oxide nanoparticles coated with either the polysaccharide, dextran, or the polymer polyethylene glycol (PEG). Nanop...

In the design of nanoparticles that can target disease tissue in vivo, parameters such as targeting ligand density, type of target receptor, and nanoparticle shape can play an important role in determining the extent of accumulation. Herein, a systematic study of these parameters for the targeting of mouse xenograft tumors is performed using superparamagnetic iron oxide as a model nanoparticle ...