The appearance of superoxide anion radical in cerebral extracellular space during and after acute hypertension induced by intravenous norepinephrine was investigated in anesthetized cats equipped with cranial windows. Superoxide was detected by demonstrating the presence of superoxide dismutase-inhibitable reduction of nitroblue tetrazolium. The superoxide dismutase-inhibitable rate of reductio...

A small portion of the oxygen consumed by aerobic cells is converted to superoxide anion at the level of the mitochondrial respiratory chain. If produced in excess, this harmful radical is considered to impair cellular structures and functions. Damage at the level of mitochondria have been reported after ischemia and reperfusion of organs. However, the complexity of the in vivo system prevents ...

Rat alveolar macrophages separated into four isopycnic fractions on Percoll gradients were functionally heterogeneous in bacterial phagocytosis, intracellular killing, superoxide anion release, and lysosomal enzyme activity but not in hydrogen peroxide release. With increasing alveolar macrophage density, phagocytosis, intracellular killing, superoxide anion release, and lysozyme activity incre...

natural antioxidants have an important role in the prevention of many age-related diseases and promotion of health. among natural antioxidants from plants, flavonoids and other phenolic compounds are potent antioxidants and chelating agents. moringa peregrina (forssk.) fiori (moringaceae) is a small desert tree distributed from tropical africa to east india. moringa tree is also growing in sout...

The present study evaluated the anti-inflammatory and analgesic effects of the superoxide dismutase mimetic agent tempol in superoxide anion-induced pain and inflammation. Mice were treated intraperitoneally with tempol (10-100 mg/kg) 40 min before the intraplantar injection of a superoxide anion donor, potassium superoxide (KO2, 30 μg). Mechanical hyperalgesia and thermal hyperalgesia, paw ede...

The present study was designed to explore the flavonoid contents and the radical scavenging activities of 50% ethanol extracts of leaves, stems, rachis and roots of Dryopteris erythrosora. The total flavonoid contents in various parts were determined as: stems > roots > rachis > leaves. All extracts from different parts of D. erythrosora showed strong bioactivities. The DPPH free radical scaven...

In order to fertilize the egg, spermatozoa must go through the capacitation process where they experience Ca2+ uptake, increases in cyclic 3',5' adenosine monophosphate (cAMP) concentrations, superoxide anion production, and protein tyrosine phosphorylation. Although the importance of these processes has been described, the interactions between them, as well as the temporal sequence of these ev...

abstract   anthocyanins are natural pigments widely spread in nature. anthocyanin color molecules are a subclass of flavonoids. they are responsible for red, purple, and blue colors of many flowers, fruits and vegetables. fruits and berries are sample sources of anthocyanins in nature. in many researches, the positive effects of fruits and berries intake on human health have been reported. anth...

the armadillo could be considered as an experimental model for leprosy studies. mycobacterium leprae main host cells are macrophages and schwann cells. however, endocytosis and germicidal activities of armadillo macrophages and monocytes have not yet been evaluated. the aim of this research was to evaluate endocytosis and nbt-reduction activities of monocyte-derived macrophages (mdm) and monocy...