1. Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993:329:977-86. 2. UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and r...

Titration of insulin dose in these patients requires serial insulin levels and or blood glucose levels. Obtaining serial insulin levels may often be difficult in a resource limited setting. As used in our patient, C-peptide levels could be used as a surrogate marker of insulin levels and could ease dose adjustment and titration during acute phases as well as during follow up. This could obviate...

BACKGROUND We aimed to analyse quantitative effects of treatment with sulphonylurea in addition to metformin on parameters of glycemic control in relation to KCNQ1 genotypes, and to identify factors predictive for the response to sulphonylurea treatment. MATERIAL/METHODS Effect of 6-month sulphonylurea therapy in addition to metformin on glycemic control according to KCNQ1 genotypes was evalu...

OBJECTIVE  To assess associations between risks of cardiovascular disease, heart failure, and all cause mortality and different diabetes drugs in people with type 2 diabetes, particularly newer agents, including gliptins and thiazolidinediones (glitazones). DESIGN  Open cohort study. SETTING  1243 general practices contributing data to the QResearch database in England. PARTICIPANTS  469 ...

A 25 year old woman suffering from recurrent attacks of hypoglycaemia underwent a laparotomy for suspected insulinoma. No tumour was found, but histology showed islet cell hyperplasia and nesidioblastosis. Although these changes have been reported as a cause of hypoglycaemia in infants, they are only rarely the cause of hypoglycaemia in adults; in the present case they were found to be the resu...

Aim: This study aimed to describe the prescription patterns of second-line medications for patients with diabetes from selected centers in Costa Rica and Panama. Methods: DISCOVER is a registry type 2 switching first- medications. We analyzed medication choice reasons switch each country. Results: A total 219 were included during 2014-2016, 127 92 The most frequently prescribed first-line was m...