Novel azobenzene based bispropargyl sulfones have been prepared in the thermally stable E-form: irradiation with a high-pressure Hg lamp converted them to the Z-isomer which showed higher DNA-cleaving efficiency.

-35Cl NQR and calorimetric measurements in BCPS have been reinvestigated between 77 K and room temperature (NQR) and between 100 K and 180 K (C~). It is shown that, in contradiction with conclusions found in literature, there is no lock-in transition at 11 5 K. These

An asymmetric organocatalysed decarboxylative protonation reaction allowed a straightforward synthesis of α-substituted isoxazolidin-5-ones from readily available 5-substituted Meldrum's acids. This process is initiated by an anionic formal (3+2) cycloaddition-fragmentation, generated in-situ from a sulfone-amide precursor which also served as a latent source of proton.

A novel and convenient copper (II) bromide and 1,8-diazabicyclo[5.4.1]undec-7-ene (DBU) or 1,10-phenanthroline catalysis protocol for the construction of α-alkyl-β-keto sulfones via C(sp(3))-H bond functionalization followed by C(sp(3))-S bond formation between aryl ketones and sodium sulfinates at room temperature has been developed. This method is applicable to a wide range of aryl ketones an...

Stud ies of histopathologic changes in denta l lesions of leprosy patients were reported by Kitami (6), Tochihara and Murakami Cl), Hirashita (~,:I) , T ajiri and Kamio (X), I takura ( .1), Kamio (f.), and Asano (1). Most of the papers of these authors were published during the period before sulfones were used in Japan, On ly the paper of Asano belongs to the later period, when sulfones were em...

The development of efficient methods for the generation of enantioenriched sulfonamides and sulfones is an important objective for fields such as organic synthesis and medicinal chemistry; however, there have been relatively few reports of direct catalytic asymmetric approaches to controlling the stereochemistry of the sulfur-bearing carbon of such targets. In this report, we describe nickel-ca...

3.3. Proteasome Inhibitors 1518 3.3.1. Peptide Aldehydes 1519 3.3.2. Boronic Acid Inhibitors 1519 3.3.3. -Lactones 1519 3.3.4. Epoxyketones 1519 3.3.5. Vinyl Sulfones 1519 3.3.6. Vinyl Ketones 1520 3.3.7. Cyclic Peptides 1520 3.3.8. Targeting of Cancer Cells 1520 4. Regulatory Particles Proteasome Activators 1520 4.1. 19S Regulatory Particle/PA70

Gold-catalysed, divergent synthesis of 2-sulfonylmethyl pyrroles and dihydropyridines from N-propargyl-N-vinyl sulfonamides has been achieved. Echavarren's gold(I) catalyst promoted the formation of pyrrole derivatives whereas the combination of PPh3AuCl and AgSbF6 afforded dihydropyridines. The aza-enyne precursors for the cycloisomerisation reaction were prepared by a base-mediated formal vin...