A new and convenient method for the construction of sulfonamides via a copper-catalyzed oxidative coupling between sodium sulfinates and amines with 1 atm O2 or DMSO as the oxidant was described. This method provides efficient and robust synthesis of functional sulfonamides in good yields and excellent chemoselectivity. And detailed mechanistic studies showed that this transformation may go thr...

An oxidative and acid-free method for the nitration of N-aryl sulfonamides has been developed using a combination of sodium nitrite as cheap and easy to handle NO2-source and the hypervalent iodine reagent PIFA as stoichiometric oxidant. Under very mild reaction conditions, the desired mononitrated aryl sulfonamides were isolated in up to 87% yield. This is the first example of an iodane-mediat...

We report a one-step procedure for the preparation of N-(2-pyrrole)-sulfonamides from sulfonamides and pyrroles. The reaction uses visible light, an acridinium dye as photocatalyst and oxygen as the terminal oxidant for the oxidative C-N bond formation; structures of several reaction products were confirmed by X-ray structure analysis. The reaction is selective for pyrroles, due to the availabl...

The Introduction in the past decade and a half of the sulfonamides and antibiotics in the treatment of bacterial infections has led to a variety of regimens In the therapy of Frledlander’s pneumonia. Both the sulfonamides and streptomycin have been used with varying degrees of success.’2 More recently aueromycln has been employed with gratifying results.3 Among the newer antibiotics, chloromyce...

Many reports have been published both in Brazil and abroad on the therapeutic results 12.5,7.8,9,10,11,12 and the side effects 3,4,14 of these drugs. SAMPAIO13 and DILLON6 concluded cn the superiority of amphotericin B when compared to separately administered sulfonamides. No studies, however, have been carried out to compare the therapeutic results obtained with amphotericin B alone and associ...

I. Sulfonamides the oldest class of antibiotics A) Structures 1) History It is appropriate to give a brief description of the history of the sulfonamides, as they were the first antibiotics developed. Scientists at Bayer in Germany discovered in the early 1930’s that protonsil rubrum, a red dye, would block infections in laboratory animals. Surprisingly, this compound did not block infections i...

A simple sugaring-out assisted liquid-liquid extraction method combined with high-performance liquid-chromatography with fluorescence detection (HPLC-FL) was developed for the extraction and determination of sulfonamides in honey. Sample preparation consisted of acid hydrolysis to release sugar-bound sulfonamides. After derivatization with fluorescamine, the derivatives were partitioned into th...

Sulfonamides and their different derivatives are extensively used in therapy due to their pharmacological properties. Sulfa drugs were amongst the oldest synthesized antimicrobial agents and are still widely used today to treat different microbial infections. Clinical treatment with sulfonamides has regained confidence with the use of a combination of sulfamethoxazole and trimethoprim to treat ...

This study focused on the presence and distribution of 22 antibiotics, including eight quinolones, nine sulfonamides and five macrolides in mollusks from the Bohai Sea of China. 190 samples of eleven species were collected in 2006, 2007 and 2009. Laboratory analyses revealed that antibiotics were widely distributed in the mollusks with quinolones as the major compounds with concentrations of 0....

Sulfonamides constitute an important class of antimicrobial agents in the world owing to their low cost, low toxicity, and excellent activity against bacterial diseases. Sulfonamides act as competitive inhibitors of the enzyme dihydropteroate synthase in bacteria, and catalyze the conversion of p-aminobenzoic acid into an essential nutrient for some bacteria [1]. After the introduction of penic...