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In two previous reports, it was shown that cocarboxylase and p-aminobenzoic acid counteract the inhibitory effect of sulfathiazole on yeast and bacterial carboxylases. Whereas cocarboxylase brings about this effect without exercising any inhibitory action on carboxylase, p-aminobenzoic acid exercises the antagonistic action to sulfathiazole while maintaining a certain degree of inhibitory effec...

Sepiapterin reductase (SPR) catalyzes the reduction of sepiapterin to dihydrobiopterin (BH2), the precursor for tetrahydrobiopterin (BH4), a cofactor critical for nitric oxide biosynthesis and alkylglycerol and aromatic amino acid metabolism. SPR also mediates chemical redox cycling, catalyzing one-electron reduction of redox-active chemicals, including quinones and bipyridinium herbicides (e.g...

Although the sulfonamide drugs are ubiquitously distributed throughout the entire body water, a property important for their wide chemotherapeutic value, quantitative differences do exist with regard to the concentrations attained in certain compartments of the extracellular fluid after equilibrium is established. Perhaps most striking is the failure of sulfathiazole to reach a concentration in...

The Permanente Journal/ Summer 2001/ Volume 5 No. 3 There have been 427 appendectomies performed in this hospital since August 1942. Fifty-one perforated appendixes were encountered. There have been no deaths in the combined series. The different pathological forms and other data of acute appendicitis with perforation, which we have encountered, are outlined in the charts below accompanied by a...

The “anomalous solubility behavior at higher pH values” of several acidic drugs originally studied by Higuchi et al. in 1953 [1], but hitherto not fully rationalized, has been re-analyzed using a novel solubilitypH analysis computer program, pDISOL-X TM . The program internally derives implicit solubility equations, given a set of proposed equilibria and constants (iteratively refined by weight...

1. In cultures of Staphylococus aureus in a synthetic medium nicotinamide and cozymase were shown to block the bacteriostatic action of chemically unrelated sulfonamide drugs as well as the chemically related compound sulfapyridine. The antibacterial properties of organic dyes totally unrelated to the sulfonamide compounds (methylene blue and thionine) were also nullified by the addition of coz...

Consumption of traces of veterinary drug residues through dairy products could have adverse effects on human health. There is, therefore, the need for routine monitoring of drug residues in dairy products on the market. In this study, fresh milk, cheese, and yogurt being sold at different points in the Kumasi metropolis were analyzed for residues of chloramphenicol, sulfathiazole, sulfamethoxaz...