In a population of approximately 100,000, 99% of the population was treated with at least one dose of sulphadimidine snuff and 94% with three or four doses over a period of two days. A dramatic reduction in the incidence of cerebrospinal meningitis followed immediately thereafter in the treated population, while the incidence continued to rise in adjacent comparable districts which had not been...

the electrochemical oxidation of sulfamethazine (smz) has been studied at a multi-walled carbon nanotubes modified glassy carbon electrode (mwcnt-gce) by cyclic voltammetry. this modified electrode (mwcnt-gce) exhibited excellent electrocatalytic behavior toward the oxidation of smz as evidenced by the enhancement of the oxidation peak current and the shift in the anodic potential to less posit...

The anaerobic isolation of anginosus group streptococci (AGS) from respiratory specimens containing diverse microbiota using a semiselective blood agar medium incorporating nalidixic acid and sulfamethazine (NAS) is described. AGS were detected in 60% of tested sputa from patients with cystic fibrosis, chronic obstructive pulmonary disease, and bronchiectasis. This demonstrates NAS to be a diag...

The effect of different doses of sulphadimidine (250, 500, 750 and 1000 mg) on acetylation capacity in 10 normal individuals was investigated in a randomized cross-over study design. The subjects were initially phenotyped with an oral dose of 750 mg of sulphadimidine. Four weeks later, each subject was assigned four different doses of sulphadimidine. The acetylator phenotype was classified for ...

Sorption of sulfamethazine (SMN) and sulfathiazole (STZ) was investigated in three soils, a North Carolina loamy sand, an Iowa sandy loam, and a Missouri loam, under various pH conditions. A significant increase in the sorption coefficient (KD) was observed in all three soils, as the sulfonamides converted from an anionic form at higher pH to a neutral/cationic form at lower pH. Above pH 7.5, s...

The appendix was investigated as a possible habitat of Streptococcus milleri. Both normal and inflamed appendices were examined and the isolation rates compared. S. milleri was present in a quarter of the normal appendices and more than half of those associated with apendicitis--a difference that was statistically highly significant. The isolation rates throughout were indepencent of age. There...

Nitrazepam is metabolized in part by nitro-reduction to an amine followed by acetylation. This acetylation step has been shown to be under the control of the same genetic polymorphism as sulphamethazine (syn: sulphadimidine).