6. Urinary tract infections.?In acute cystitis and pyelitis and in chronic infection due to coli bacilli sulphanilamide is adequate but sulphacetamide has been particularly recommended because of its high solubility in urine. Its sodium salt (albucid soluble) may be injected intravenously in 30 per cent solution. Sulphathiazole or sulphadiazine may be given in resistant cases. The average daily...

In the course of a study of the mammalian metabolism of succinate, liver slices derived from rabbits previously given intraperitoneal injections of sodium pantothenate were incubated with succinic acid-l ,4-Cl4 and sulfanilamide (1). Acetylsulfanilamide isolated from the reaction mixture proved to be radioactive, and degradation revealed that all of the Cl* in this product resided in the carbox...

Diseases characterized by out-of-control cell growth are known as cancer. One of the most important mechanisms for handling it is the inhibition of the human topoisomerase II receptor. In same context while studying the treatment of cancer we found the significant effects of the derivatives of the sulfonamides, this promotes us to design novel derivatives by the means of in-silico resources wit...

Antibiotics have been used to control the aquatic environment in both therapeutic and prophylactic ways. are particularly difficult extract due their strong interactions with biological matrices. In this study, UPLC-MS/MS method was developed validated for quantitative confirmatory analysis of multi-class antibiotics residues fish shrimp. Fourteen belonging sulphonamides, β-lactams, quinolones,...

A new, rapid and simple method is described and applied to resolve and quantify mixtures of prednisolone acetate, sulfacetamide and phenylefrine. The determination was accomplished by micellar electrokinetic capillary chromatography (MEKC) using a fused silica capillary (57 cm x 75 microm ID). The separation was carried out at 25 degrees C and 30 kV, using a 5 mM phosphate-5 mM borate buffer ad...

An intelligent wine detection and traceability method based on infrared spec-troscopy machine learning is proposed, in order to meet the needs of online rapid nondestructive testing wine. On basis extracting spectrum wine, principal component analysis (PCA) – support vector (SVM) model was modified by chemometrics. A total 300 grape samples were collected from six production areas. The composit...

Department of Biochemistry, Faculty of Pharmacy, October 6th University, October 6th city, Egypt E-mail : [email protected] ABSTRACT-: This study was carried out to evaluate the structure activity relationship and biochemical effects of some novel of anti-inflammatory triazoloquinazolines and triazinoquinazolines containing sulfacetamide moiety. Some of the newly synthesized compoun...