introduction: several lines of evidence suggest that the factor xiii (fxiii) 100 g/t polymorphism may influence susceptibility to deep venous thromboembolism (dvt). to explore this hypothesis, we investigated whether this polymorphism is associated with the predisposition to dvt. we also predict the possible impact of residue substitution at codons 34 (val34leu) in a subunits of the fxiii coagu...

sulphosalts in the system agsbs2-agass2 have been experimentally investigated using dry methods. the solid solutions which form between ?-miargyrite and smithite have different structures. the epma data for the solid solution series show that there is an inverse relation between sb and as. the cell parameters of the solid solution between ?-miargyrite and smithite increase up to about 50% of...

sulphosalts in the system agsbs2-agass2 have been experimentally investigated using dry methods. the solid solutions which form between ?-miargyrite and smithite have different structures. the epma data for the solid solution series show that there is an inverse relation between sb and as. the cell parameters of the solid solution between ?-miargyrite and smithite increase up to about 50% of ag...

Interspecific germplasm introgression enables unique opportunities for genetic analysis and improvement of domesticated plants, but is commonly impeded by barriers to transmission and recombination, insufficient genetic resolution, and the difficulty of deriving economically suitable products. Such impediments are mitigated to varying extents by the breeding of chromosome substitution lines; ho...

Craniopharyngioma is a rare benign intracranial epithelial tumor that, however, often recurs and sometimes kills the affected patients, one-third of which are children. In many cases, the patients acquire growth hormone deficiency and postoperatively need substitution. Generally, growth hormone promotes local release of insulin-like growth factor I (IGF-I), which in turn activates the IGF-I rec...

In this work, we report the synthesis of three series carbohydrate-based benzo[f]indole-4,9-diones and amino-1,4-naphthoquinone derivatives evaluated their cytotoxic activity against eight human cancer cell lines. Several compounds showed a promising toward tumor lines (half maximal inhibitory concentration (IC50) < 10.0 ?M). The importance substitution pattern quinone on antitumor was also dis...

The mass-specific metabolic rate hypothesis of Gillooly and others predicts that DNA mutation and substitution rates are a function of body mass and temperature. We tested this hypothesis with sequence divergences estimated from mtDNA cytochrome b sequences of 54 taxa of cyprinid fish. Branch lengths estimated from a likelihood tree were compared with metabolic rates calculated from body mass a...

We examined mutations in BRAF exons 11 and 15 and N-RAS exons 2 and 3, in 77 metastatic melanoma cases and 11 melanoma cell lines. Significant differences in the mutation rates observed at different metastatic sites could not be detected. The most frequent mutation, the V599E amino acid substitution in BRAF exon 15, was observed in 31 of 77 (40%) tissues and 5 of 11 (45%) cell lines. Tandem bas...

The major virulence determinant of the rodent malaria parasite, Plasmodium yoelii, has remained unresolved since the discovery of the lethal line in the 1970s. Because virulence in this parasite correlates with the ability to invade different types of erythrocytes, we evaluated the potential role of the parasite erythrocyte binding ligand, PyEBL. We found 1 amino acid substitution in a domain r...