Abstract: Aim/Background: Parkinson’s Disease (PD), the loss of dopaminergic neurons in substantial nigra part brain leading to neurodegeneration. Materials and Methods: The objective this study was observe neuroprotective effect synthesized derivatives 6-hydroxydopamine (6-OHDA) induced rat model. Here, designed naphthalene substituted azetidinone compounds defended lesions caused by 6-OHDA mo...

fibers of poplar wood (populus nigra l.) were prepared and oven dried. afterwards, they were acetylated with acetic anhydride without a catalyst. acetylation was carried out for different durations at 120ºc. different weight percentage gains (wpgs) were achieved based on the operating conditions. acetylated fibers were exposed to varying levels of relative humidity to determine equilibrium mois...

The main strategy in experimental and clinical neural transplantation in Parkinson's disease has been to place fetal nigral grafts not in their ontogenic site (substantia nigra) but in their target area (striatum). The reason for this ectopic placement is the apparent inability of nigral grafts placed in the ventral mesencephalon (VM) of the adult host to grow axons for long distances that are ...

Substantial evidence indicates that neuroinflammation caused by microglial activation in substantia nigra is critical in the pathogenesis of dopaminergic neurodegeneration in Parkinson's disease (PD). Increasing data demonstrates that environmental factors such as rotenone, paraquat play pivotal roles in dopaminergic neuron death. Here, potential role and mechanism of neuromelanin (NM), a major...

Substantial evidence indicates that subjective value is adapted to the statistics of reward expected within a given temporal context. However, how these contextual expectations are learned is poorly understood. To examine such learning, we exploited a recent observation that participants performing a gambling task adjust their preferences as a function of context. We show that, in the absence o...

Most in vivo electrophysiological studies of substantia nigra have used rats. With the recent proliferation of the use of mice for in vitro neurophysiological studies because of the availability of various genetically modified strains to identify the roles of various channels and proteins in neuronal function, it is crucial to obtain data on in vivo responses in mice to verify that the in vitro...

The present study describes the distribution and cellular morphology of catecholaminergic neurons in the diencephalon and midbrain of the bottlenose dolphin (Tursiops truncatus). Tyrosine hydroxylase immunohistochemistry was used to visualize these putatively dopaminergic neurons. The standard A1-A17, C1-C3, nomenclature is used for expediency; however, the neuroanatomical names of the various ...

Background: Microbial resistance to antibiotics has led serious efforts discover novel drugs, which is why there so much interest in the use of herbs. Therefore, aim this study was investigate antibacterial effect aqueous, hydro-alcoholic, and alcoholic extracts Morus nigra comparison with some common antibiotics. Method: In experimental study, zone inhibition, minimum inhibitory concentration ...