BACKGROUND Postoperative antiepileptic drug (AED) withdrawal practices remain debatable and little is known about the optimum timing. We hypothesised that early AED withdrawal does not affect long-term seizure outcome but allows identification of incomplete surgical success earlier than late withdrawal. We aimed to assess the relation between timing of AED withdrawal and subsequent seizure recu...

While comparing the drug withdrawal and availability pattern among different countries, we can see that some drugs withdrawn in one country continue to be used at other places. This may be due to valid reasons like difference in disease pattern, prescribing practice, genetics, diet; drug manufacturing process used which influence pharmaceutical quality and composition, dose and availability. Bu...

Freshwater resources are fundamental for maintaining human health, agricultural production, economic activity as well as critical ecosystem functions. As populations and economies grow, new constraints on water resources are appearing, raising questions about limits to water availability. Such resource questions are not new. The specter of "peak oil"--a peaking and then decline in oil productio...

This study explored the relationships of demographic, work perception, work attitude, and limited occupation alternative variables to three distinct types of occupation perceptions: forced to stay in occupation (FTSO), voluntary occupation withdrawal intent (VOWI), and involuntary occupation withdrawal (IOW). An online sample of massage therapists and bodywork practitioners constituted the stud...

A transactional model examining the longitudinal association between vagal regulation (as indexed by vagal withdrawal) and maternal sensitivity from age 2.5 to age 5.5 was assessed. The sample included 356 children (171 male, 185 female) and their mothers who participated in a laboratory visit at age 2.5, 4.5, and 5.5. Cardiac vagal tone was obtained during a baseline task and during emotional ...

Alternative designs can increase the feasibility of pediatric trials when compared to classical parallel designs (PaD). In this work we present a model-based approach based on clinical trial simulations for the comparison of PaD with the alternative sequential, crossover, and randomized withdrawal (RWD) designs. Study designs were evaluated in terms of: type I and II errors, sample size per arm...

Anxiety sensitivity (AS) is a cognitive, individual difference variable characterized by a fear of arousal-related bodily sensations due to beliefs that such sensations are signs of impending catastrophic physical, psychological, or social outcomes. AS has been linked to increased risk for the development and maintenance of panic attacks and anxiety disorders, and more recently has been related...