Zhang Y, Catalán MA, Melvin JE. TRPV4 activation in mouse submandibular gland modulates Ca influx and salivation. Am J Physiol Gastrointest Liver Physiol 303: G1365–G1372, 2012. First published October 18, 2012; doi:10.1152/ajpgi.00366.2012.—Transient receptor potential vanilloid subtype 4 (TRPV4) is a ligand-gated nonselective cation channel that participates in the transduction of mechanical ...

  The effects of gentamicin, lithium and combination of these drugs on ultrastructural morphology of rat submandibular glands were studied. Daily intraperitoneal injection of 40 mg/kg of gentamicin which causes chronic salivary gland toxicity, led to a marked decrease in gland's dry weight and total protein concentration but did not affect DNA content. Electron micrograph (EM) of submandibular ...

Mucoceles occur most commonly in the oral mucosa and minor salivary glands. The lower lip is the most common site for the development of a mucocele, and occurrence in one of the major salivary glands is rare. A review of literature written in English revealed 13 cases of submandibular gland mucocele. The etiology of mucoceles is thought to involve partial obstruction or disruption of the saliva...

BACKGROUND Dysgenetic polycystic salivary gland disease is a rare pathology. No case of minor salivary gland involvement has been reported in the literature. METHODS A female patient presented with bilateral tumors of the parotid glands, bilateral submandibular gland enlargement, and multiple cystic lesions of the oral mucosa. MRI of the neck was performed along with fine-needle aspiration (F...

The B1-immunoreactive proteins (B1-IPs) are major secretory products of rat submandibular gland acinar-cell progenitors, and are also produced by neonatal and adult rat sublingual and parotid glands. In order to characterize the B1-IPs, we have previously isolated cDNA clones encoding rat parotid secretory protein (PSP; the predominant parotid B1-IP) and the related clone ZZ3, which is developm...

Objective: One of the indexes that best shows oral health status is decayed-missing-filled teeth (DMFT) index. 65% saliva secreted in body produced by submandibular gland. imaging methods gland ultrasound. The aim this study to investigate whether there a relationship between volume gland, which most, and DMFT In addition, changes size salivary depending on age, gender mass index (BMI) were inv...

BACKGROUND The purpose of this retrospective chart review was to determine whether and how the submandibular gland is involved in metastases of squamous cell carcinoma of the head and neck. METHODS We reviewed the records of all patients for whom pathology specimens were available after neck dissection for primary head and neck cancers at two institutions. RESULTS One hundred sixty-nine pat...

BACKGROUND The indications for reduction of excessive submandibular gland volume in aesthetic rejuvenation of the neck have been well described, as has the surgical anatomy and the surgical technique. Despite this, submandibular gland reduction does not appear to be widely adopted, nor have significant case series been reported in the literature. This review of a consecutive series of aesthetic...

BACKGROUND Leiomyosarcoma is a rare malignant mesenchymal tumor that represents 5-7 % of all soft tissue sarcomas. The occurrence of this tumor in the salivary glands is exceptional. Only five cases are reported in the submandibular gland. CASE PRESENTATION A 65-year-old white Moroccan woman presented with a history of progressive right submandibular swelling which had grown over a period of ...