Background: An andrographolide analogue, 3,19-isopropylideneandrographolide (IPAD), exert an inhibitory effect on herpes simplex virus serotype 1 (HSV-1) wild types replication. In this study, we examined the anti-viral activity of IPAD on HSV-1 and HSV-2 wild types and HSV-1 drug-resistant strains (DRs). Synergistic effects of IPAD with ACV were also evaluated. Methods: MTT and plaque reductio...

Apple released the first iPad in 2010, and since then various operating systems have emerged. Many corporations have adopted the use of tablets in efforts toward organizational innovation. Innovation is the motivation for organizations to move forward and it is a key in the maintenance of their competitive advantage. The Environmental Protection Administration (EPA) of Taiwan started to use the...

The traditional methods of drug discovery follow the "one drug-one target" approach, which ignores the cellular and physiological environment of the action mechanism of drugs. However, pathway-based drug discovery methods can overcome this limitation. This kind of method, such as the Integrative Penalized Matrix Decomposition (iPaD) method, identifies the drug-pathway associations by taking the...

       Cholera toxin B subunit (CtxB) is a homopantameric, nontoxic subunit of cholera toxin that is responsible for its binding to the cell and has been known as a mucosal adjuvant for vaccines that could increase homoral and mocusal immunity response. In this work, the CtxB gene was fused to the StxB gene from Shigella dysenteriae type I a vaccine antigen candidate against t...

Mobile learning (M-learning) has become a popular topic in educational research, in previous research there have been many studies on attitude to M-learning directed towards staff, parents and students; however, limited research has focused on the comparison between teachers and students in the context of creative engineering and their respective opinions on issues of M-learning (iPad-based), c...

Our purpose was to compare reading performance measured with the MNREAD Acuity Chart and an iPad application (app) version of the same test for both normally sighted and low-vision participants. Our methods included 165 participants with normal vision and 43 participants with low vision tested on the standard printed MNREAD and on the iPad app version of the test. Maximum Reading Speed, Critica...

BACKGROUND An andrographolide analogue, 3, 19-isopropylideneandrographolide (IPAD), exerts an inhibitory effect on replication of wild-type herpes simplex virus serotype 1 (HSV-1). In this study, we examined the anti-viral activity of IPAD on HSV wild types (HSV-1 strain KOS and HSV-2 clinical isolate) and HSV-1 drug-resistant strains (DRs). Synergistic effects of IPAD with acyclovir (ACV) were...