As whole genome shotgun sequencing (WGSS) becomes more accessible using high-throughput sequencing technologies, undertaking comparative studies among different individuals (based on population, race, or genetic disease) is the next logical step. In this paper, we propose a paradigm shift in variation comparative studies (specifically structural variation) away from the conventional two step ap...

Our understanding of the molecular structures of amyloid fibrils that are associated with neurodegenerative diseases, of mechanisms by which disease-associated peptides and proteins aggregate into fibrils, and of structural properties of aggregation intermediates has advanced considerably in recent years. Detailed molecular structural models for certain fibrils and aggregation intermediates are...

Structural variations are widespread in the human genome and can serve as genetic markers in clinical and evolutionary studies. With the advances in the next-generation sequencing technology, recent methods allow for identification of structural variations with unprecedented resolution and accuracy. They also provide opportunities to discover variants that could not be detected on conventional ...