The antinociceptive action of cannabinoids in acute and inflammatory pain states have been well-documented. There is also accumulating evidence suggesting that cannabinoids are effective analgesics in chronic pain conditions. WIN 55,212-2, a mixed CB1 and CB2 cannabinoid receptor agonist, has been shown to be effective against hyperalgesia and allodynia in painful peripheral mononeuropathy. Rec...

Background and Objective: Lowering serum glucose and lipid levels in diabetic patients by using natural materials is of great importance. In this study, the effect of oral consumption of Fumaria Parviflora Lamwas was assessed on serum glucose and lipid levels in streptozocin diabetic rats. Materials and Methods: In this experimental study, 32 male Wistar rats were divided into four groups of co...

Objective: Herbal medicine and medical plants such as Ziziphus Jujuba are widely used in the treatment of diseases such as diabetes mellitus. We investigated the effects of ethanol extracts of Ziziphus Jujuba fruit on serum glucose, triglycerides, LDL-cholesterol, HDL-cholesterol, cholesterol and activities of aminotransferase enzymes in streptozocin-induced diabetic adult male rats. Materials...

Expression of voltage-gated K(+) channels encoding the K(+) independent transient outward current in the streptozocin-induced diabetic (DM) rat ventricle was studied to determine the basis for slowed cardiac repolarization in diabetes mellitus. Although hypertrophy was not detected in diabetic rats at 12 wk after streptozocin treatment, ventricular Kv4.2 mRNA levels decreased 41% relative to no...

In islet transplantation, nonimmunological factors such as limited growth capacity or increased death rate could reduce the beta cell mass in the graft and lead to failure of the transplant. We studied the evolution of beta cell replication and mass after transplantation of insufficient, minimally sufficient, or excessive islet tissue. Streptozocin diabetic C57BL/6 mice received 150 or 300 syng...