INTRODUCTION Suppression is a major sensorial abnormality in humans and monkeys with infantile strabismus. We previously reported evidence of metabolic suppression in the visual cortex of strabismic macaques, using the mitochondrial enzyme cytochrome oxidase as an anatomic label. The purpose of this study was to further elucidate alterations in cortical metabolic activity, with or without ambly...

Amblyopia can be produced in rhesus monkeys by suturing the lids of one eye (visual deprivation amblyopia) or by producing artificial esotropia (strabismic amblyopia) during visual immaturity. Sections from retinas, lateral geniculate nuclei (LGN), and areas 17 and 18 of the visual cortex from monkeys with behaviorally proved amblyopia and cortical neurophysiologic changes were examined histolo...

PURPOSE To compare visual evoked potentials (VEPs) and contrast sensitivity in adults with early- or late-onset strabismic amblyopia. METHODS Twelve adults with early- and 12 with late-onset strabismic amblyopia with similar ranges of visual acuity were studied. Pattern-onset VEPs to 30-minute checks were recorded at a range of contrast levels. Contrast sensitivity (CS) was measured at 3.2 cy...

Approved by the following research ethics committee: Federal University of São Paulo (approval no 0503/08). ABSTRACT Purpose: To evaluate visual acuity and transient pattern reversal (PR) visual evoked potentials (VEPs) in the fellow eyes of children with strabismic and/or anisometropic amblyopia. Methods: Children diagnosed with strabismic and/or anisometropic amblyopia were recruited for elec...

PURPOSE In order to better understand whether white matter structural deficits are present in strabismic amblyopia, we performed a survey of the tissue properties of 28 major white matter tracts using diffusion and quantitative magnetic resonance imaging approaches. METHODS We used diffusion-based tensor modeling and a new quantitative T1 protocol to measure fractional anisotropy (FA), mean d...

Amblyopia is the most common cause of monocular visual impairment in both children, and young to middle-aged adults, affecting 2%–5% general population. The objective this study was compare peripapillary nerve fiber thickness macular amblyopic eyes, fellow eyes normal control using spectral domain optical coherence tomography. This a cross-sectional observational conducted at R M Kedia Eye Hosp...

PURPOSE We performed a qualitative assessment of fixation behaviour in relation to the fovea in patients with strabismic amblyopia. METHODS The fixation of 25 patients with strabismic amblyopia was examined using a scanning laser ophthalmoscope (SLO). A digital frame grabber board was programmed to scan onto the patient's retina single solid black discs of 5, 10 and 15 degrees in diameter and...

Direction discrimination thresholds for maximum motion displacement (D(max)) have been previously reported to be abnormal in amblyopic children [Ho, C. S., Giaschi, D. E., Boden, C., Dougherty, R., Cline, R., & Lyons, C. (2005). Deficient motion perception in the fellow eye of amblyopic children. Vision Research, 45, 1615-1627; Ho, C. S., & Giaschi, D. E. (2006). Deficient maximum motion displa...