Purpose: In this article we studied the effect of the packaging material on the liquid stability of interferon alpha 2b (rhIFN-α2b). Methods: The compatibility of this cytokine with type I borosilicate glass ampoules was evaluated by ELISA and RP-HPLC, at 4oC and after heat sealing. Additionally, the influence of protein concentration (3 and 10 MIU/ml), buffer species (sodium phosphate, sodium ...

We describe a 7-month outbreak of nosocomial Burkholderia cepacia bacteremia involving eight children in a pediatric hospital and the results of epidemiological investigations. A B. cepacia strain genotypically identical to the blood isolates was recovered from the upper surface of capped rubber stoppers of bottles of a commercial lipid emulsion used for parenteral nutrition.

Two independent beam stoppers have been developed for improving the separation of gas-filled recoil ion separator GARIS-II. Performance evaluation these supplemental was performed by using 208Pb (18O,3n)223Th reaction. A160-fold enhancement signal-to-noise ratio at GARIS-II focal plane observed.

AIM In short-term studies, hormonal contraceptives (HC) have been suggested to induce a rise in blood pressure (BP) and urinary albumin excretion (UAE), while the effect of HC in renal function (GFR) is still under debate. Data on long-term and withdrawal effects of HC use on these outcomes are, however, not available. We therefore studied whether the start and cessation of HC induce changes in...

The bacterial toxin colicin Ia forms voltage-gated channels in planar lipid bilayers. The toxin consists of three domains, with the carboxy-terminal domain (C-domain) responsible for channel formation. The C-domain contributes four membrane-spanning segments and a 68-residue translocated segment to the open channel, whereas the upstream domains and the amino-terminal end of the C-domain stay on...

Mechanical stoppers in MEMS capacitive systems can dramatically affect electrical performances and result complicated mechanical dynamic responses. This paper introduces electromechanical coupling nonlinear responses variable dual-capacitor with an effect of asymmetrical stoppers. We found that the capacitance circuit system related to first-order derivative output voltage on a load resistor, w...