stk11

Increased tissue factor expression is associated with reduced survival in non-small cell lung cancer and with mutations of TP53 and PTEN.

Journal: :Clinical chemistry 2009

Sandra Regina Jean-Baptiste Valentin Sébastien Lachot Etienne Lemarié Jérôme Rollin Yves Gruel

BACKGROUND Tissue factor (TF), the main initiator of blood coagulation, is also a signaling protein that regulates cancer progression. TF synthesis was recently shown to be affected by tumor suppressor genes (TSGs) in tumor cell lines. We therefore studied TF gene (F3) expression and the status of genes coding for tumor protein p53 (TP53), phosphatase and tensin homolog (PTEN), and serine/threo...

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Construction of a prognostic prediction system for pancreatic ductal adenocarcinoma to investigate the key prognostic genes

2018

Bingli Zheng Jie Peng Ablikim Mollayup Ahmat Bakri Lei Guo Jianjiang Zheng Hui Xu

Pancreatic cancer (PC) is associated with high mortality rates and poor prognoses. Pancreatic adenocarcinoma is the most common type of PC, and almost all cases of pancreatic adenocarcinoma are pancreatic ductal adenocarcinoma (PDAC). The aim of the current study was to reveal the genes involved in the prognosis of PDAC. Five datasets, including GSE71729 (145 PDAC samples and 46 normal samples)...

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Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1.

Journal: :Carcinogenesis 2010

Martha L Slattery Jennifer S Herrick Abbie Lundgreen Francis A Fitzpatrick Karen Curtin Roger K Wolff

Serine/threonine protein kinase 11 (STK11) and phosphatase tensin homolog deleted on chromosome 10 (PTEN) link insulin sensitivity and metabolic signaling to inflammation and other hormonal factors and colorectal cancer. We evaluate genetic variation in nine genes in a candidate pathway as follows: STK11 (3 tagSNPs), PTEN (9 tagSNPs), FRAP1 (mTOR) (4 tagSNPs), TSC1 (14 tagSNPs), TSC2 (8 tagSNPs...

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Differential Pathogenesis of Lung Adenocarcinoma Subtypes Involving Sequence Mutations, Copy Number, Chromosomal Instability, and Methylation

2012

Matthew D. Wilkerson Xiaoying Yin Vonn Walter Ni Zhao Christopher R. Cabanski Michele C. Hayward C. Ryan Miller Mark A. Socinski Alden M. Parsons Leigh B. Thorne Benjamin E. Haithcock Nirmal K. Veeramachaneni William K. Funkhouser Scott H. Randell Philip S. Bernard Charles M. Perou D. Neil Hayes

BACKGROUND Lung adenocarcinoma (LAD) has extreme genetic variation among patients, which is currently not well understood, limiting progress in therapy development and research. LAD intrinsic molecular subtypes are a validated stratification of naturally-occurring gene expression patterns and encompass different functional pathways and patient outcomes. Patients may have incurred different muta...

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شناسایی تغییرات نوکلئوتیدی دو ژن شناخته شده (brca۲ و stk۱۱) عامل سرطان پستان ارثی در یک خانواده ایرانی به روش تعیین توالی اگزوم

ژورنال: :پژوهش های آسیب شناسی زیستی 0

mojgan ataei-kachouei department of medical genetics, faculty of medical sciences, tarbiat modares university, tehran, iran javad nadaf department of human genetics, mcgill university, montreal, canada mohammad taghi akbari department of medical genetics, faculty of medical sciences, tarbiat modares university, tehran, iran morteza atri cancer research institute, tehran university of medical sciences, tehran, iran jacek majewski mcgill university and genome quebec innovation center, montreal, canada yasser riazalhosseini mcgill university and genome quebec innovation center, montreal, canada masoud garshasbi

هدف: از زمان شناسایی دو ژن پرنفوذ brca1/2 با وراثت بارز در دهه 1990 تاکنون ژن‏های مختلفی شناسایی شده‏است که در مجموع حدود 25 درصد اساس ژنتیکی سرطان پستان ارثی را توضیح می‏دهد و حداقل 75 درصد آن همچنان ناشناخته باقی مانده است. هدف از انجام این مطالعه بررسی وجود یا عدم وجود الگوی وراثتی مغلوب در این بیماری هتروژن است که احتمال وجود آن توسط برخی از محققین مطرح شده است. مواد و روش‏ها: در این مطالعه...

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Increased tissue factor expression is associated with reduced survival in non-small cell lung cancer and with mutations of TP53 and PTEN.

Construction of a prognostic prediction system for pancreatic ductal adenocarcinoma to investigate the key prognostic genes

Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1.

Differential Pathogenesis of Lung Adenocarcinoma Subtypes Involving Sequence Mutations, Copy Number, Chromosomal Instability, and Methylation

شناسایی تغییرات نوکلئوتیدی دو ژن شناخته شده (brca۲ و stk۱۱) عامل سرطان پستان ارثی در یک خانواده ایرانی به روش تعیین توالی اگزوم

Mutational Analysis of STK11 h Gene in Ovarian Carcinomas

A child with an STK11 mutation and Sotos syndrome-like features: can STK11 mutations produce a Sotos syndrome phenocopy?

Analysis Of STK11/LKB1 Gene Using Bioinformatics Tools

Emerging Therapeutic Implications of STK11 Mutation: Case Series

Peutz-Jeghers syndrome with germline mutation of STK11