نتایج جستجو برای: steroid sulphatase

تعداد نتایج: 45445  

Journal: :FEBS letters 1973
B Arborgh T Berg J L Ericsson

The two acid hydrolases ‘acid phosphatase’ (orthophosphoric monoester phosphohydrolase, EC 3.1.3.2) and ‘aryl sulphatase’ (aryl-sulphate sulphohydrolase, EC 3.1.6.1) are both enzymes which are known to be present in the lysosomes of almost all cell types [cf. l] . Histochemical studies have revealed apparent activity of acid phosphatase in both hepatic parenchymal and Kupffer cells [2,3] , and ...

Journal: :Endocrine-related cancer 2008
Joanna M Day Helena J Tutill Atul Purohit Michael J Reed

17beta-Hydroxysteroid dehydrogenases (17beta-HSDs) are enzymes that are responsible for reduction or oxidation of hormones, fatty acids and bile acids in vivo, regulating the amount of the active form that is available to bind to its cognate receptor. All require NAD(P)(H) for activity. Fifteen 17beta-HSDs have been identified to date, and with one exception, 17beta-HSD type 5 (17beta-HSD5), an...

Journal: :Reproductive biology 2012
Sławomir Zduńczyk Tomasz Janowski Andrzej Raś Wojciech Barański

The activities of steroid sulphatase (StS) and estrogen sulphotransferase (EST) were determined in the epididymis of 18 boars. The animals were divided into three groups (n=6) according to age (8, 12 and 16 months). The boars were anesthetized and castrated. The tissue samples of different epididymal parts (caput, corpus and cauda) were taken and homogenized. Activities of StS and EST were asse...

Journal: :Human reproduction 2008
A Purohit L Fusi J Brosens L W L Woo B V L Potter M J Reed

BACKGROUND Local biosynthesis of estrogens is thought to be important for the maintenance and growth of endometriotic implants. In addition to the formation of estrogen via the aromatase pathway, steroid sulphatase (STS), which is responsible for the hydrolysis of estrogen sulphates, may be an important source of estrogens in endometriosis. METHODS Eutopic and ectopic endometrial samples from...

Journal: :The Biochemical journal 1987
C Freeman P R Clements J J Hopwood

Human N-acetylglucosamine-6-sulphate sulphatase was purified at least 50,000-fold to homogeneity in 78% yield from liver with a simple three-step four-column procedure, which consists of a concanavalin A-Sepharose/Blue A-agarose coupled step, chromatofocusing and Cu2+-chelating Sepharose chromatography. In all, four forms were isolated and partially characterized. Forms A and B, both with a pI ...

2015
Oana Mărginean Lorena Elena Melit Oana Marginean Carmen Duicu Cristina Campean Maria Oana Marginean

Mucopolysaccharidoses (MPSs) are a group of rare genetic disorders within the larger family of lysosomal diseases. MPSs disorders are caused by a defi ciency in the activity of a specifi c lysosomal enzyme required for the degradation of glycosaminoglycans (GAGs). MPS type II, also called Hunter syndrome consists in a defi ciency of an enzyme, iduronate-2-sulphatase. We present a rare case of H...

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