BACKGROUND Studies of the psychosomatic correlates of self-excoriative behavior in acne have involved mainly women with acne excorieé. Little is written about the psychosomatic factors that affect men with acne. Excessive self-excoriation of acne lesions is an important clinical factor because it can prolong the course of the disease and exacerbate the deeper inflammatory process with an increa...

Congenital adrenal hyperplasia (CAH) due to steroid 11β-hydroxylase deficiency is the second most common form of CAH, resulting from a mutation in the CYP11B1 gene. Steroid 11β-hydroxylase deficiency results in excessive mineralcorticoids and androgen production leading to hypertension, precocious puberty with acne, enlarged penis, and hyperpigmentation of scrotum of genetically male infants. I...

BACKGROUND Oral isotretinoin (Roaccutane) revolutionized the treatment of acne when it was introduced in 1982. METHODS Twelve dermatologists from several countries with a special interest in acne treatment met to formally review the survey of their last 100 acne patients treated with oral isotretinoin. The primary purpose of the survey was to identify the types of acne patients who were presc...

BACKGROUND Acne vulgaris is a common skin disease with a large quality of life impact, characterized by comedones, inflammatory lesions, secondary dyspigmentation, and scarring. Although traditionally considered a disease of adolescence, reports suggest it is also a disease of adults, especially adult women. Our objectives were to determine acne prevalence in a large, diverse group of women and...

to determine the prognostic value of response to treatment in patients with focal segmental glomerulo-sclerosis. fsgs includes 10-15% of idiopathic nephrotic syndrome in children. bulk of evidence supports disease relationship with immune system. unfortunately, responses to immunosuppressive drugs are not desirable and progression to end-stage renal disease is common. we analyzed 62 out of 99 c...

Daun bandotan (Ageratum conyzoides Lin) merupakan salah satu tanaman yang digunakan sebagai obat tradisional daun mempunyai berbagai khasiat, satunya antibakteri Tujuan penelitian ini adalah mengetahui efek ekstrak terhadap pertumbuhan bakteri Propionumbacterium acnes, Escherichia coli, dan Streptococcus mutan. Simplisia diekstrak menggunakan etanol pada suhu kamar, kemudian dilakukan pemekatan...

Introduction Although there is widespread acceptance of a relationship between stress and acne, not many studies have been performed to assess this relationship. The objective of this study was to determine the relationship between stress and acne severity. Methods A cross-sectional study was conducted among 144 6th year female medical students 22 to 24 years in age attending the medical facu...

Introduction: Acne vulgaris is a frequently encountered skin disease in daily practice. Its clinico-epidemiological status was evaluated in this study. Methods: Four hundred patients were studied by record-based observation for 2 years in the Acne Clinic of a tertiary care hospital. Results: This study revealed a male preponderance (53%) with a higher prevalence in adolescents (75%). Women with...

Epidermal growth factor (EGF) acts as a paracrine and autocrine mediator of cell proliferation differentiation in various types epithelial cells, such sebocytes, which produce the lipid-rich sebum to moisturize skin. However, lipids via direct contact by penetrating through epidermis may have regulatory roles on epidermal dermal cells well. As EGF receptor (EGFR) is expressed throughout prolife...

The skin locally synthesizes significant amounts of sexual hormones with intracrine or paracrine actions. The local level of each sexual steroid depends upon the expression of each of the androgen- and estrogen-synthesizing enzymes in each cell type, with sebaceous glands and sweat glands being the major contributors. Sebocytes express very little of the key enzyme, cytochrome P450c17, necessar...