The silyl- and germylzincation of terminal or internal propargylic alcohols by reaction with (Me3Si)3SiH/Et2Zn, [(Me3Si)3Si]2Zn/Et2Zn Ph3GeH/Et2Zn is examined. These reactions proceed through the addition silicon- germanium-centered radicals across carbon≡carbon triple bond followed trapping diethylzinc produced vinyl radical homolytic substitution at zinc atom. influence hydroxy unit on regio-...

Oxazolidinone-substituted enecarbamates offer a system to explore vibrational quenching and the strategic placement of CH bonds as a method for manipulating the stereoselectivity of photoreactions.

The use of a non-coordinating solvent for the aza-Claisen rearrangement of delta,epsilon-disubstituted acetimidates switches on a substrate directing effect that gives excellent stereoselectivity.

A general strategy for fast decarboxylative difunctionalization to gem-dihalohydrin, gem-dihaloether, gem-dibromoester and cyclized bromo-1,4-dioxane synthons with outstanding regio- and stereoselectivity is demonstrated.

Treatment of arylacetylenes and cyanogen bromide in ClCH(2)CH(2)Cl with a catalytic amount of GaCl(3) afforded (Z)-β-bromoacrylonitriles with high regio- and stereoselectivity.

Physical and chemical quenching rate constants were measured for the reaction of singlet oxygen with oxazolidinone-functionalized enecarbamates to investigate the role of vibrational deactivation in product stereoselectivity.

We describe our studies on the effect of various Lewis bases and Brønsted acids as achiral additives on the stereoselectivity of some Rh(ii)-catalyzed cyclopropanations.

The inhibitory effects of local anesthetics (LAs) of cocaine and bupivacaine optical isomers on Na+ currents were studied in clonal GH3 cells under whole-cell patch clamp conditions. At holding potential of -100 mV, all four isomers inhibited peak Na+ currents when the cell was stimulated infrequently. The dose-response curves of this tonic block of peak Na+ currents by (-)/(+) cocaine and (-)/...