نتایج جستجو برای: stearoyl coa desaturase 1 scd 1
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Chronically elevated levels of fatty acids-FA can cause beta cell death in vitro. Beta cells vary in their individual susceptibility to FA-toxicity. Rat beta cells were previously shown to better resist FA-toxicity in conditions that increased triglyceride formation or mitochondrial and peroxisomal FA-oxidation, possibly reducing cytoplasmic levels of toxic FA-moieties. We now show that stearoy...
A higher content of C16:1 n-10 has recently been reported in the preputial gland of mice with a targeted disruption of the gene encoding stearoyl-CoA desaturase 1 (SCD1 / mice) when compared with wild-type mice. This result has provided the first physiological evidence for the presence and regulation of a palmitoyl-CoA 6-desaturase in mammals. To investigate the putative involvement of the know...
A hallmark of targeted cancer therapies is selective toxicity among cancer cell lines. We evaluated results from a viability screen of over 200,000 small molecules to identify two chemical series, oxalamides and benzothiazoles, that were selectively toxic at low nanomolar concentrations to the same 4 of 12 human lung cancer cell lines. Sensitive cell lines expressed cytochrome P450 (CYP) 4F11, ...
The objectives of this study were 1) to determine whether selection toward less subcutaneous fat thickness at constant intramuscular fat content in pigs is related to tissue-specific changes in the expression of lipogenic enzymes acetyl-CoA carboxylase (ACC), stearoyl-CoA desaturase (SCD), and Delta(6)-desaturase (Delta6d); and 2) to investigate tissue specific distribution of the porcine ACC, ...
Stearoyl-CoA desaturase-1 (SCD-1) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids (MUFA), which are required for efficient neutral lipid esterification. In the present investigation, we demonstrate that loss of SCD-1 activity increases free cholesterol (FC) content and induces Xbp-1 splicing. We assessed the small molecule SCD-1 inhibitor A939572 on [(14)C]stearat...
MEMBRANE TOPOLOGY OF MOUSE STEAROYL-COA DESATURASE 1 Weng Chi Man*, Makoto Miyazaki*, Kiki Chu*, and James M. Ntambi* From the Departments of *Biochemistry and ¶Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706 Running Title: Mouse SCD1 Topology Address correspondence to: James M. Ntambi, Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madi...
The mammalian target of rapamycin (mTOR) has been shown to play a central role in regulating cell growth and metabolism. However, little is known about the function mTOR nutrient metabolism bivalve mollusks. In this study, regulation was investigated Sinonovacula constricta. First, activation assayed after starvation refeeding. Afterwards, using an activator (MHY1485) or inhibitor (rapamycin) m...
Growing consumer awareness is forcing food producers to supply raw material and products of increasingly high quality health-promoting properties. Knowledge the genetic background characteristics taking on great importance, enabling selection based molecular markers. The increasing throughput techniques, in combination with an expanding bioinformatics infrastructure, leading continual improveme...
Stearoyl-CoA desaturase (SCD) catalyzes the rate-limiting step in the biosynthesis of monounsaturated fatty acids. Mice with a targeted disruption of the SCD1 isoform have reduced body adiposity, increased energy expenditure, and up-regulated expression of several genes encoding enzymes of fatty acid beta-oxidation in liver. The mechanisms by which SCD deficiency leads to these metabolic change...
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